Biological therapies for psoriasis: Adherence and outcome analysis from a clinical perspective

The Australasian Journal of Dermatology
Christopher RossTyman Stanford

Abstract

We evaluated and compared patients' long-term adherence to biological therapies in a real-life clinical setting. Secondary aims included weight changes on biological therapy and reporting adverse effects. This prospective case-note review included 58 patients, undergoing 84 treatment series including etanercept (21), adalimumab (24), infliximab (14) and ustekinumab (25). Patients' adherence was greatest with ustekinumab (being 6.7-fold less likely to withdraw from treatment than etanercept, P = 0.014), while the difference in treatment adherence of adalimumab and infliximab compared to etanercept was not statistically significant. Adalimumab and infliximab were associated with an increase in weight, while ustekinumab was associated with weight loss compared with etanercept (not statistically significant). Long-term patient adherence to biologic therapy in patients with psoriasis is greatest with ustekinumab.

References

Mar 21, 2000·Archives of Dermatology·K Adetugbo, H Williams
Jun 14, 2005·The British Journal of Dermatology·K A PappUNKNOWN Etanercept Psoriasis Study Group
Nov 17, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·P GisondiG Girolomoni
Sep 24, 2008·The British Journal of Dermatology·R B WarrenC E M Griffiths
Oct 30, 2013·The Australasian Journal of Dermatology·Eugene TanPeter Foley

❮ Previous
Next ❯

Citations

Oct 22, 2015·Expert Review of Pharmacoeconomics & Outcomes Research·Nicole C RouseSteven R Feldman
Jun 22, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·Q MagisUNKNOWN “Groupe de Recherche sur le Psoriasis de la Société Française”
Nov 24, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Tobias ArnoldWiebke K Peitsch
Nov 24, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Tobias ArnoldWiebke K Peitsch
Nov 4, 2017·The Journal of Dermatological Treatment·G CarreteroUNKNOWN from the Spanish Group of Psoriasis
Oct 28, 2017·The Journal of Dermatological Treatment·Daniel J NoJashin J Wu
Aug 25, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Joseph S AleshakiSteven R Feldman
Aug 10, 2017·The Journal of Dermatological Treatment·Lilla PogácsásAndrea Szegedi
Feb 8, 2019·The British Journal of Dermatology·A MouradR Gniadecki
Aug 28, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·L EicherA Wollenberg
Dec 5, 2019·Experimental and Therapeutic Medicine·Madalina MocanuTatiana Taranu
May 11, 2016·Expert Opinion on Drug Delivery·Melissa B HoffmanSteven R Feldman
Oct 10, 2018·Dermatology : International Journal for Clinical and Investigative Dermatology·Antonio CostanzoCarlotta Galeone
Jan 13, 2018·Expert Review of Clinical Immunology·Lauren SealeSteven R Feldman
May 16, 2021·Journal of Cardiovascular Pharmacology·Bruce A Warden, Paul Barton Duell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.