Biological therapy increases the health-related quality of life in patients with inflammatory bowel disease in a clinical setting

Scandinavian Journal of Gastroenterology
Anne Sofie Krogh HoldamJens Frederik Dahlerup

Abstract

Inflammatory bowel diseases (IBDs) have a considerable impact on the health-related quality of life (HRQoL) of patients. We aimed to investigate the effect of biological therapy on HRQoL in IBD patients followed in an out-patient clinical setting and to compare the HRQoL scores to that of IBD patients without disease activity. Observational and retrospective study in patients treated with biologics. A Short Health Scale (SHS) questionnaire on HRQoL consisting of four items (bowel symptoms, interference in daily life, worry, and general well-being) was completed and registered in each patient's medical journal. Data on HRQoL was collected at the beginning of treatment and every 3 months thereafter. The biologically treated group was compared with a control group of IBD patients without disease activity. We identified 114 patients who began a new round of biological treatment. These were either naïve to biologics or had a break in treatment for more 3 months. After 3 months of therapy, significant improvements in HRQoL compared to baseline were observed for every item on the SHS (p value < 0.01). Subgroup analysis showed a poorer HRQoL performance in women, patients with Crohn's disease, and smokers. The median HRQoL score regard...Continue Reading

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Citations

Jan 30, 2019·Medical Sciences : Open Access Journal·Nirmala SarwanVijay Kumar Chattu
Jun 24, 2020·Current Medical Research and Opinion·Roberta RobertiGiovambattista De Sarro
Jul 12, 2019·Journal of the Canadian Association of Gastroenterology·Jennifer L JonesAnthony R Otley
Jun 6, 2020·Journal of Clinical Medicine·Ferdinando D'AmicoLaurent Peyrin-Biroulet
May 17, 2019·Journal of Psoriasis and Psoriatic Arthritis·Sara Jiayang LiJoseph F Merola
Oct 28, 2019·Arthritis Care & Research·Lisa H BuckleyPamela F Weiss

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