Biological variability of C-reactive protein and specific canine pancreatic lipase immunoreactivity in apparently healthy dogs

Journal of Veterinary Internal Medicine
P C CarneyJörg M Steiner

Abstract

C-reactive protein (CRP) and specific canine pancreatic lipase immunoreactivity (Spec cPL) are biomarkers of generalized or nonspecific inflammation and pancreatic inflammation in dogs, respectively. The extent of inter- and intraindividual variation over time of these analytes is not well defined in dogs. The minimal critical difference for sequential determinations of these markers (ie, the smallest change necessary to represent physiological change rather than biological variation), has not been defined. To determine the inter- and intraindividual variability (CV(G) and CV(I) ) and minimal critical difference for sequential determinations of serum CRP and Spec cPL concentrations in apparently healthy dogs. Eleven apparently healthy dogs owned by staff or students at a veterinary teaching hospital. Blood was collected repeatedly at varying intervals over 12 weeks. CRP and Spec cPL concentrations were determined with commercially available assays. Indices of inter-, intraindividual, and assay variability and 1-sided minimal critical differences for sequential concentrations were calculated. For CRP, CV(G) was 90.8%, CV(I) was 115.5%, and the analytical variability (CV(A) ) was 6.3%; the index of individuality was 0.74, and 1-s...Continue Reading

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Citations

Aug 7, 2012·Veterinary Clinical Pathology·Panagiotis G Xenoulis, Jörg M Steiner
Nov 6, 2012·Veterinary Clinical Pathology·Emma M StrageInger Lilliehöök
Nov 28, 2012·American Journal of Veterinary Research·Romy M HeilmannJörg M Steiner
Apr 5, 2014·Journal of Veterinary Internal Medicine·J D FosterL A Trepanier
May 21, 2011·Topics in Companion Animal Medicine·Olivier Dossin
May 15, 2013·Journal of Veterinary Internal Medicine·D WalkerO A Garden
Aug 26, 2015·Journal of the South African Veterinary Association·Liza S KösterJohan P Schoeman
Dec 18, 2014·Journal of the American Veterinary Medical Association·Mirjam EquilinoIwan A Burgener Dvm
Apr 4, 2017·Veterinary Clinical Pathology·Kathleen P FreemanAsger L Jensen
Feb 23, 2018·Journal of Veterinary Internal Medicine·M A KopkeA Gal
Aug 29, 2018·Veterinary Clinical Pathology·Bente FlatlandRandolph M Baral
Sep 18, 2018·Journal of Veterinary Internal Medicine·Romy M Heilmann, Jörg M Steiner
Oct 27, 2017·Journal of Veterinary Emergency and Critical Care·Romy M HeilmannJames W Barr
Jan 15, 2016·Veterinary Clinical Pathology·Romy M HeilmannJörg M Steiner
Jul 28, 2020·Veterinary Clinical Pathology·Jennifer M PrietoMark E Peterson
Nov 15, 2020·The Veterinary Clinics of North America. Small Animal Practice·Juan Hernandez, Julien Rodolphe Samuel Dandrieux
Jun 5, 2021·Journal of Veterinary Internal Medicine·Max ForemanSalih Eminaga
Jun 15, 2021·Frontiers in Veterinary Science·Elettra FeboAndrea Boari

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