Biological Variability of Estimated GFR and Albuminuria in CKD

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Sushrut S WaikarChronic Kidney Disease Biomarkers Consortium Investigators

Abstract

Determining whether a change in estimated glomerular filtration rate (eGFR) or albuminuria is clinically significant requires knowledge of short-term within-person variability of the measurements, which few studies have addressed in the setting of chronic kidney disease. Cross-sectional study with multiple collections over less than 4 weeks. Clinically stable outpatients with chronic kidney disease (N=50; mean age, 56.8 years; median eGFR, 40mL/min/1.73m2; median urinary albumin-creatinine ratio (UACR), 173mg/g). Repeat measurements from serially collected samples across 3 study visits. Measurements of urine albumin concentration (UAC), UACR, and plasma creatinine, cystatin C, β2-microglobulin (B2M), and beta trace protein (BTP). We calculated within-person coefficients of variation (CVw) values and corresponding reference change positive and negative (RCVpos and RCVneg) values using log-transformed measurements. Median CVw (RCVpos; RCVneg) values of filtration markers were 5.4% (+16%; -14%) for serum creatinine, 4.1% (+12%; -11%) for cystatin C, 7.4% (+23%; -18%) for BTP, and 5.6% (+17%; -14%) for B2M. Results for albuminuria were 33.2% (+145%; -59%) for first-morning UAC, 50.6% (+276%; -73%) for random spot UAC, 32.5% (+141%;...Continue Reading

Associated Clinical Trials

Citations

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Oct 13, 2019·Physiological Reports·Sheeba Ba AqeelUNKNOWN Diabetes Control, Complications Trial (DCCT)/Epidemiology of Diabetes Interventions, Complications (EDIC) Study
Nov 12, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Friedrich C PrischlChristoph Wanner
Sep 19, 2019·Nature Reviews. Nephrology·Andrew S LeveyLesley A Inker
Apr 9, 2020·Diabetes, Obesity & Metabolism·Nicholas M Selby, Maarten W Taal
Sep 8, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Sri Lekha Tummalapalli, Carmen A Peralta
May 9, 2019·Journal of Cellular and Molecular Medicine·Tim LangeNicole Endlich
Feb 7, 2020·Journal of the American Society of Nephrology : JASN·Josef Coresh
Apr 25, 2020·Journal of Nephrology·Guillaume RésimontPierre Delanaye
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Aug 1, 2020·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Daniel BunoutEduardo Lorca
Feb 16, 2021·JAMA Internal Medicine·Chi-Yuan Hsu, Alan S Go
Oct 15, 2018·Journal of Diabetes and Its Complications·Anna R KahkoskaUNKNOWN SEARCH for Diabetes in Youth Study Group
Jun 2, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshTeresa K Chen
May 11, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brian KwanUNKNOWN CRIC Study Investigators
Sep 4, 2021·Current Opinion in Nephrology and Hypertension·Azadeh Zabetian, Steven G Coca

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