PMID: 9166965Apr 1, 1997Paper

Biological variation in protein C, protein S and antithrombin concentrations in plasma of healthy subjects

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
G V Melzi d'ErilR Trotti

Abstract

The analytical, intra- and inter-individual components of biological variation were estimated for protein C, protein S and antithrombin over a period of 6 weeks in a cohort of 17 apparently healthy subjects. Expressed as percentage activity (protein C and antithrombin) as a percentage concentration in normal human plasma (protein S), the mean values for men and women show no significant differences (p > 0.05) for any of the analytes studied. Calculated analytical goals (CV, %) for precision required for optimal patient care are: protein C, 2.9; protein S, 2.9 and antithrombin 2.7. A single numerical index, called "index of fiduciality", was also calculated to demonstrate that the analytical performance of our method was satisfactory. The generally applicable differences (% activity or % concentration) required for two results to be significantly different (p < or = 0.05) were calculated as: protein C, 17; protein S, 16 and antithrombin, 16. The usefulness of critical differences as guidelines for the interpretation of changes in serial results was investigated using an "index of heterogeneity" of intra-individual variation. The marked degree of individuality demonstrated for all the quantities indicates that, if conventional po...Continue Reading

References

Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·C G Fraser, E K Harris
Jan 1, 1983·Advances in Clinical Chemistry·C G Fraser
Jan 1, 1980·CRC Critical Reviews in Clinical Laboratory Sciences·C G Fraser, M J Peake
Dec 1, 1970·Journal of Chronic Diseases·E K Harris

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