Biological variations in hyperlipidemic children and adolescents treated with fenofibrate

Clinica Chimica Acta; International Journal of Clinical Chemistry
J SteinmetzP Drouin

Abstract

Beside their pharmacological action drugs may have unexpected side effects which must be known and taken into account in the interpretation of laboratory tests. In this work, we followed 17 hyperlipidemic subjects, aged 4-19 years, treated with fenofibrate only. We performed several plasma tests before and during treatment. The hypolipidemic action of fenofibrate was evident: decreases of cholesterol and triglycerides mean values were, respectively, 22% and 39% after 3 months of treatment. Other plasma constituents were also significantly decreased: uric acid, 20%; bilirubin, 19%; alkaline phosphatases, 15%. The aminotransferase activities (both AST and ALT) were increased in only four subjects after 3 months. The highest values were 88 U/l for AST and 109 U/l for ALT (the initial values were, respectively, 28 U/l and 23 U/l). These activities decreased when the treatment was stopped. These variations were isolated and transient.

References

Sep 1, 1976·The American Journal of Digestive Diseases·D A SaltzmanS F Robinson
Aug 1, 1974·Annals of Internal Medicine·W C BaileyH A Jackson

❮ Previous
Next ❯

Citations

May 24, 2003·Current Diabetes Reports·Kenneth Lee Jones, Asheesh Kumar Dewan
Sep 5, 2002·Atherosclerosis·Emanuel GanotakisMoses Elisaf
Aug 19, 2007·Médecine sciences : M/S·Daniel LambertSophie Visvikis-Siest
Jan 1, 1991·Annals of the New York Academy of Sciences·J M Hoeg
Feb 23, 2002·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toru HayakawaNobuo Inotsume
Aug 29, 2007·International Journal of Nanomedicine·Konstantinos Tziomalos, Vasilios G Athyros
Aug 11, 2000·Paediatric Drugs·S Tonstad
Mar 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B KasiskeUNKNOWN National Kidney Foundation
Sep 8, 2015·Journal of Clinical Lipidology·Rae-Ellen W Kavey
Jul 16, 2014·Kidney International Supplements
Oct 26, 1999·The Annals of Pharmacotherapy·D R Guay
Jan 24, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chiara MameliCristiana Perrotta
Apr 8, 2014·Clinical Pediatrics·Sarah D de FerrantiStavroula K Osganian
Jan 3, 2012·Physiotherapy Canada. Physiothérapie Canada·Anne Ayling CamposPatricia A McGrath
Sep 1, 2008·Expert Review of Endocrinology & Metabolism·Lorenzo IughettiFiorella Balli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.