Biological variations of seven tumor markers

Clinica Chimica Acta; International Journal of Clinical Chemistry
Zhihong QiWei Cui

Abstract

We sought to identify biological variations in the following tumor markers: pepsinogen I (PGI), pepsinogen II (PGII), carbohydrate antigen 724 (CA724), neuron-specific enolase (NSE), pro-gastrin-releasing peptide (ProGRP), carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199). Serum samples were collected from 20 healthy Chinese individuals over 5 days. Samples were then screened for the presence of the seven aforementioned tumor markers. Within-individual coefficient of variation (CVI), between-individual coefficient of variation (CVG), confidence interval (CI) of biological variations, index of individuality (II), and the reference change value (RCV) of the seven tumor markers were calculated. Of the 7 tumor markers, index of individuality was all <1.0. ProGRP showed the lowest CVI and CVG, at 4.75% (CI: 3.96%-5.94%) and 16.42% (CI: 12.32%-24.61%), respectively. The 95% and 99% RCVs for ProGRP were 14.68 and 19.32, respectively, and were the lowest of the markers. In contrast, the CVI and CVG for CA724 were the highest, at 16.06% (CI: 13.83%-19.17%) and 96.95% (CI: 73.73%-141.59%), respectively. The 95% and 99% RCVs for CA724 were the highest, at 45.89 and 60.41, respectively. Our findings provide additional in...Continue Reading

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Citations

Oct 30, 2016·Journal of Clinical Laboratory Analysis·Selcuk MatyarTamer Inal
Apr 19, 2018·Critical Reviews in Clinical Laboratory Sciences·Konstantinos MakrisGeorgios Tsivgoulis
Sep 20, 2017·Journal of Clinical Laboratory Analysis·Shuo WangHong Shang
Jan 12, 2019·Critical Reviews in Clinical Laboratory Sciences·Edward W Randell, Sedef Yenice
Nov 30, 2019·Journal of Clinical Laboratory Analysis·Xiaorong ZhouJianwei Lu
May 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Abdurrahman CoşkunUNKNOWN European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Biological Variation

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