Biological Versus Chronological Aging: JACC Focus Seminar

Journal of the American College of Cardiology
Magda R HamczykVicente Andrés

Abstract

Aging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide. In a progressively aging population, it is essential to develop early-life biomarkers that efficiently identify individuals who are at high risk of developing accelerated vascular damage, with the ultimate goal of improving primary prevention and reducing the health care and socioeconomic impact of age-related cardiovascular disease. Studies in experimental models and humans have identified 9 highly interconnected hallmark processes driving mammalian aging. However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations.

Citations

Apr 29, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Amalia Peix
Aug 9, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Jia ShiFan He
Sep 29, 2020·Hypertension·Mieczysław Litwin, Janusz Feber
Aug 10, 2020·Current Atherosclerosis Reports·Fabiana Rached, Raul D Santos
Oct 2, 2020·Cardiovascular Research·João Pedro FerreiraFaiez Zannad
Oct 21, 2020·Expert Opinion on Drug Metabolism & Toxicology·Dorsa MaherEmily Reeve
Jan 16, 2021·Atherosclerosis·Elaine R CoutinhoRaul D Santos
Jan 19, 2021·Journal of the American Heart Association·Takumi ToyaAmir Lerman
Feb 5, 2021·Mechanisms of Ageing and Development·Jacopo SabbatinelliFabiola Olivieri
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui ZhangChangwei Liu
Dec 19, 2020·Biomedicines·Natalia RybtsovaStanislav Rybtsov
Feb 20, 2021·Journal of the American College of Cardiology·Valentin Fuster
Feb 24, 2021·Ageing Research Reviews·M Cristina PolidoriThomas Benzing
Mar 12, 2021·History and Philosophy of the Life Sciences·Hane Htut Maung
Mar 25, 2021·European Journal of Preventive Cardiology·Gianfranco Parati, Sergio Caravita
Mar 22, 2021·JACC. Cardiovascular Imaging·Vineet K RaghuMichael T Lu
Nov 14, 2020·Scientific Reports·Lorenzo Dall'OlioHae-Won Uh
Mar 29, 2021·Journal of Psychosomatic Research·Milán Vecsey-NagyJános Nemcsik
Mar 12, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mei Sum ChanSarah Parish
Apr 12, 2021·Progress in Cardiovascular Diseases·Alberto PalazzuoliUNKNOWN Italian Society of Cardiology Heart Failure Study Group
May 26, 2021·Translational Psychiatry·Pei-Fen KuanBenjamin J Luft
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikola GligorijevićTanja Ćirković Veličković
Jun 4, 2021·Ageing Research Reviews·Fabiola OlivieriMassimiliano Bonafè
Jul 2, 2021·Journal of the American Medical Directors Association·Pedro Luis Cepas-GuillénManel Sabate
May 22, 2021·The Journal of Clinical Endocrinology and Metabolism·Assaf BuchNaftali Stern
Jul 11, 2020·Journal of the American College of Cardiology·Rachel E ClimieDimitrios Terentes-Printzios
Jul 28, 2021·Aging Cell·Nellie Y LohConstantinos Christodoulides
Aug 8, 2021·Heart, Lung & Circulation·Christopher Clemens MayerElisabetta Bianchini
Aug 19, 2021·The Journal of Clinical Endocrinology and Metabolism·Assaf BuchNaftali Stern
Aug 16, 2021·Ageing Research Reviews·Aurelia SantoroDaniela Monti
Jul 10, 2021·Journal of the American College of Cardiology·Borja IbanezValentín Fuster
Aug 27, 2021·Nature Communications·Emilly M LimaAntonio Luiz P Ribeiro
Aug 29, 2021·Heart, Lung & Circulation·Ute SeelandUNKNOWN Sex and Gender VascAgeNet Expert Group
Sep 4, 2021·The International Journal of Cardiovascular Imaging·Ivan LechnerSebastian Johannes Reinstadler
Oct 1, 2021·Circulation·Jason D RobertsGregory M Marcus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Related Papers

Advances in Experimental Medicine and Biology
Kang XuZhao Wang
Proceedings of the National Academy of Sciences of the United States of America
Daniel W BelskyTerrie E Moffitt
Advances in Experimental Medicine and Biology
Natalie ThomasJayashri Kulkarni
Advances in Experimental Medicine and Biology
Xiao-juan Bai
© 2021 Meta ULC. All rights reserved