PMID: 11918063Mar 29, 2002Paper

Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities

The Journal of Antibiotics
Bärbel KöpckeH Anke

Abstract

Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.

Citations

Sep 28, 2006·Natural Product Reports·Hua Wei ZhangRen Xiang Tan
Feb 2, 2012·The Journal of Antibiotics·Antonio EvidenteMaurizio Vurro
Aug 2, 2007·Organic Letters·Hélène Lebel, Michaël Parmentier
May 1, 2021·International Journal of Environmental Research and Public Health·K Kiran Kumar, Surendra K Dara

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