Biologically active tetranorditerpenoids from the fungus Sclerotinia homoeocarpa causal agent of dollar spot in turfgrass.

Journal of Natural Products
H M T Bandara HerathN P Dhammika Nanayakkara

Abstract

Nine new tetranorditerpenoid dilactones (2-10), together with two previously reported norditerpenoids dilactones (1, 11), and two known putative biosynthetic intermediates, oidiolactone-E (12) and 13, were isolated from an ethyl acetate extract of a culture medium of Sclerotinia homoeocarpa. Structures and absolute configurations of these compounds were determined by spectroscopic methods and confirmed by X-ray crystallographic analysis of representative compounds. Compounds were evaluated for herbicidal, antiplasmodial, and cytotoxic activities. Compounds 1, 2, 6, 7, and 11 were more active as growth inhibitors in a duckweed bioassay (I(50) values of 0.39-0.95 microM) than more than half of 26 commercial herbicides previously evaluated using the same bioassay. Some of these compounds exhibited strong antiplasmodial activities as well, but they also had cytotoxic activity, thus precluding them as potential antimalarial agents.

References

Jan 1, 1988·Antonie van Leeuwenhoek·G W Van EijkH A Van der Aa
Sep 9, 1970·Journal of the American Chemical Society·G A EllestadG O Morton
Jul 18, 2000·Journal of Agricultural and Food Chemistry·F A MacíasD Jiménez-González
Feb 15, 2001·Biochemical Society Transactions·H K Lichtenthaler
Nov 21, 2001·The Journal of Antibiotics·K IchikawaN Kojima
Jan 5, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·S A RalphG I McFadden
Mar 1, 2003·Journal of Natural Products·George R PettitRobin K Pettit
Jun 3, 2004·Nature Reviews. Drug Discovery·David A FidockSolomon Nwaka
Oct 31, 2006·Bioorganic & Medicinal Chemistry·Sandip B BharateInder Pal Singh
Feb 3, 2007·Natural Product Reports·Richard N Strange
Sep 11, 2007·Biological & Pharmaceutical Bulletin·Joanna BajsaBabu Lal Tekwani

❮ Previous
Next ❯

Citations

Jul 27, 2011·The Journal of Organic Chemistry·José AlemánCarmen Navarro Ranninger
Aug 21, 2012·PloS One·Angela M OrshinskyMichael J Boehm
Jan 27, 2015·Natural Product Reports·John W BluntMichèle R Prinsep
Jun 30, 2011·Natural Product Reports·James R Hanson
Jan 7, 2014·Natural Product Reports·John W BluntMichèle R Prinsep
Nov 22, 2019·Journal of Food Science·Carolina Girotto PresseteLuciana Azevedo
Feb 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mallika KumarihamyN P Dhammika Nanayakkara
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mallika KumarihamyN P Dhammika Nanayakkara
Sep 29, 2020·Mini Reviews in Medicinal Chemistry·Syed ShabanaA Krishna Satya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.