Biologically effective doses in medium dose rate brachytherapy of cancer of the cervix

Radiation Oncology Investigations
F LeborgneR Chappell

Abstract

The amount of dose reduction on changing from low dose rate (LDR) brachytherapy to medium dose rate (MDR) or high dose rate (HDR) afterloading has been the subject of much debate. The magnitude of reduction depends, together with other possible factors, on two radiobiological parameters: the alpha/beta ratio and the half-time of repair of the relevant tissues. In an attempt to extract these radiobiological parameters for the late rectal complications observed in our previously published clinical results four different schedules using MDR and one using LDR are analyzed. The percentage incidence of complications was a function of increasing biologically effective dose (BED), but would yield nonsense scattergrams if plotted against raw total dose. In addition, for three other published MDR series, three LDR series, and two HDR series, the incidence of rectal complications is plotted against BED to examine the predictive potential of using BED as the surrogate of total dose. Our own results were published in 1996, consisting of 102 patients treated at the LDR of 0.44 Gy/hr and 88 patients treated by four different schedules using an MDR of 1.6-1.7 Gy/hr. Follow-up is at least 3 years in all schedules. The linear quadratic formula i...Continue Reading

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Citations

Jun 19, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P C O'Brien
Jul 7, 2010·The British Journal of Radiology·J F Fowler
Dec 3, 2002·International Journal of Radiation Oncology, Biology, Physics·Brij SoodBhadrasain Vikram
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Aug 20, 2010·Radiation Research·Katsutoshi SatoHiroaki Nishimura
Jun 26, 2020·Medical Physics·V Y Kuperman, L M Lubich

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