Biologically Functional Ultrathin Films Made of Zwitterionic Block Copolymer Micelles

Langmuir : the ACS Journal of Surfaces and Colloids
Sinem UlusanIrem Erel-Goktepe

Abstract

We report the preparation of ultrathin coatings of zwitterionic block copolymer micelles and a comparison of their protein adsorption, adhesiveness, and antibacterial properties. Zwitterionic block copolymer micelles were obtained through pH-induced self-assembly of poly[3-dimethyl(methacryloyloxyethyl)ammonium propanesulfonate- b-2-(diisopropylamino)ethyl methacrylate] (βPDMA- b-PDPA) at pH 7.5. βPDMA- b-PDPA micelles with zwitterionic βPDMA-corona and pH-responsive PDPA-core were then used as building blocks to prepare layer-by-layer (LbL) assembled multilayer films together with hyaluronic acid (HA), tannic acid (TA), or poly(sodium 4-styrenesulfonate) (PSS). Protein adsorption tests showed that 3-layer βPDMA- b-PDPA micelles/HA films were the most effective to reduce the adhesion of BSA, lysozyme, ferritin, and casein. In contrast, βPDMA- b-PDPA micelles/TA films were the most attractive surfaces for protein adsorption. Bacterial antiadhesive tests against a model Gram-negative bacterium, Escherichia coli, and a model Gram-positive bacterium, Staphylococcus aureus, were in good agreement with the protein adsorption properties of the films. The differences in the antiadhesive properties between these three different film sys...Continue Reading

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Citations

Dec 15, 2020·Biomaterials·Victoria AlbrightSvetlana A Sukhishvili
Feb 23, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Nicholas A MoringoChristy F Landes
Jan 18, 2022·Langmuir : the ACS Journal of Surfaces and Colloids·David H ChoJong-In Hahm
Jan 22, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Gnanasekar SathishkumarYunlong Yu

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