Biologics Delay Progression of Crohn's Disease, but Not Early Surgery, in Children

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Basavaraj KerurNeal Leleiko

Abstract

Up to 30% of patients with Crohn's disease (CD) require surgery within the first 5 years from diagnosis. We investigated the recent risk of bowel surgery in an inception cohort of pediatric patients with CD and whether early use of biologics (tumor necrosis factor antagonists) alters later disease course. We collected data from the Pediatric Inflammatory Bowel Disease Collaborative Research Group registry on 1442 children (age, ≤16 y) diagnosed with CD from January 2002 through December 2014. Data were collected at diagnosis, 30 days following diagnosis, and then quarterly and during hospitalizations for up to 12 years. Our primary aim was to determine the 10-year risk for surgery in children with CD. Our secondary aim was to determine whether early use of biologics (<3 mo of diagnosis) affected risk of disease progression. The 10-year risk of first bowel surgery was 26%. The 5-year risk of bowel surgery did not change from 2002 through 2014, and remained between 13% and 14%. Most surgeries occurred within 3 years from diagnosis. The only predictor of surgery was disease behavior at diagnosis. CD with inflammatory behavior had the lowest risk of surgery compared to stricturing disease, penetrating disease, or both. We associate...Continue Reading

Citations

Jun 28, 2019·Inflammatory Bowel Diseases·Cortney Ballengee Menchini
May 10, 2020·Inflammatory Bowel Diseases·Basavaraj KerurMichael D Kappelman
Oct 16, 2019·Journal of Paediatrics and Child Health·Zubin Grover, George Alex
May 1, 2020·Journal of Gastroenterology and Hepatology·Montserrat GuaschUNKNOWN GETECCU-ENEIDA registry
Jun 18, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C MaP G Kotze
Mar 2, 2021·Frontiers in Pediatrics·Anastasia KonidariMunir Pirmohamed
Sep 28, 2020·Seminars in Ultrasound, CT, and MR·S G HarringtonMichael S Gee
Jul 7, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Henit YanaiUNKNOWN Israeli IBD Research Nucleus
Sep 30, 2021·The American Journal of Gastroenterology·Parambir S DulaiWilliam J Sandborn

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