Biologics in SAPHO syndrome: A systematic review

Seminars in Arthritis and Rheumatism
Dimitrios DaoussisStamatis-Nick Liossis

Abstract

The SAPHO syndrome is a relatively rare clinical entity characterized by a wide range of dermatological and musculoskeletal manifestations. Biologics have been used in cases refractory to conventional treatment. We present herein a patient with refractory to treatment SAPHO syndrome who exhibited a dramatic and fast response to IL-17 blockade. Additionally, we performed a systematic review of all cases of patients with SAPHO syndrome treated with biologics to date. We identified 66 cases treated with biologics (45 with TNF blockers, 7 with IL-1 blockers, 13 with biologics targeting the IL-23/IL-17 axis, and 1 with tocilizumab). Data support a positive effect of anti-TNF treatment in SAPHO with a response rate in bone and joint manifestations of 93.3%. Skin disease also improved in 21/29 cases (72.4%). Data related to IL-1 inhibition in SAPHO are encouraging with most patients exhibiting a significant response in musculoskeletal manifestations (6/7, 85.7%). However, IL-1 inhibition is not effective in skin manifestations. Ustekinumab seems to have some efficacy with 2/4 patients responding in skin and 3/5 in bone/joint manifestations. Data related to IL-17 blockade indicate efficacy in skin disease with 4/7 patients responding (...Continue Reading

Citations

Feb 15, 2019·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Sophie-Caroline CampanaRémi Esclassan
Sep 19, 2019·Acta Physiologica·Chunsheng ZhuZheng Zhou
May 15, 2020·Expert Opinion on Drug Safety·Ilaria MaccoraGabriele Simonini
Apr 19, 2019·American Journal of Clinical Dermatology·Annika Havnaer, George Han
May 11, 2020·Clinical Rheumatology·Clémence Ferreira-VilacaThibault Canceill
Jun 12, 2020·Therapeutic Advances in Musculoskeletal Disease·Shuang LiuChen Li
Sep 17, 2020·Journal of Surgical Case Reports·Sena HoriguchiKatsumi Doi
Jul 18, 2019·Clinical Rheumatology·Adelaide Sofia Batalha FigueiredoMaria Francisca Moraes-Fontes
Jan 9, 2019·BMJ Case Reports·Chin-Fang SuChang-Youh Tsai
Jul 25, 2020·Current Rheumatology Reports·Christian M HedrichHermann J Girschick
Jun 13, 2020·Annals of the Rheumatic Diseases·Wenhui XieZhuoli Zhang
Aug 4, 2020·Current Opinion in Rheumatology·Aleksander Lenert, Polly J Ferguson
Jan 7, 2021·Dermatologic Therapy·Gaetano LicataGiuseppe Argenziano
Jan 26, 2021·Modern Rheumatology Case Reports·Haruka TsuchiyaKeishi Fujio
Dec 6, 2020·Current Opinion in Pediatrics·Fernando Moreno-MateoKaren Brandt Onel
Apr 20, 2021·Journal of Translational Autoimmunity·Dan Yongdong ZhaoChristian M Hedrich
Jun 18, 2021·International Journal of Rheumatic Diseases·Masahiro KondoMayuko Moriyama
Aug 22, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·Gai GeHongsheng Wang
Sep 18, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Georgios NikolakisChristos C Zouboulis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Rheumatology Reports
Davide FirinuStefano R del Giacco
Inflammation & Allergy Drug Targets
Davide FirinuStefano R del Giacco
Dermatology Online Journal
Rana AbdatMichael K Lichtman
Joint, Bone, Spine : Revue Du Rhumatisme
Daniel WendlingClément Prati
© 2022 Meta ULC. All rights reserved