Biology and Function of miR159 in Plants

Plants
Anthony A MillarGigi Wong

Abstract

MicroR159 (miR159) is ancient, being present in the majority of land plants where it targets a class of regulatory genes called GAMYB or GAMYB-like via highly conserved miR159-binding sites. These GAMYB genes encode R2R3 MYB domain transcription factors that transduce the gibberellin (GA) signal in the seed aleurone and the anther tapetum. Here, GAMYB plays a conserved role in promoting the programmed cell death of these tissues, where miR159 function appears weak. By contrast, GAMYB is not involved in GA-signaling in vegetative tissues, but rather its expression is deleterious, leading to the inhibition of growth and development. Here, the major function of miR159 is to mediate strong silencing of GAMYB to enable normal growth. Highlighting this requirement of strong silencing are conserved RNA secondary structures associated with the miR159-binding site in GAMYB mRNA that promotes miR159-mediated repression. Although the miR159-GAMYB pathway in vegetative tissues has been implicated in a number of different functions, presently no conserved role for this pathway has emerged. We will review the current knowledge of the different proposed functions of miR159, and how this ancient pathway has been used as a model to help form ou...Continue Reading

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Citations

Feb 9, 2020·Plants·Anthony A Millar
Mar 19, 2020·International Journal of Molecular Sciences·Jingyi MaHuihong Guo
Aug 28, 2020·Plant & Cell Physiology·Sha Yu, Jia-Wei Wang
Feb 23, 2020·Chemosphere·Sinchan AdhikariZahed Hossain
Mar 29, 2021·The New Phytologist·Changkui GuoGang Wu
Jun 3, 2021·International Journal of Molecular Sciences·Carlos Lopez-OrtizUmesh K Reddy
Jul 11, 2021·Plant Physiology and Biochemistry : PPB·Sudhakar Srivastava, Penna Suprasanna
Jul 15, 2021·Journal of Experimental Botany·Carlos Hernán Barrera-RojasFabio Tebaldi Silveira Nogueira
Aug 8, 2021·International Journal of Molecular Sciences·Yilin JiangXiangyuan Wan
Aug 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Namisha SharmaManoj Prasad
Aug 13, 2021·BMC Plant Biology·Roshan RegmiMark C Derbyshire

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Methods Mentioned

BETA
transgenic

Software Mentioned

psRNATarget

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