Biology and mechano-response of tendon cells: Progress overview and perspectives

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Hui B SunJames H-C Wang

Abstract

In this review, we summarize the group discussions on Cell Biology & Mechanics from the 2014 ORS/ISMMS New Frontiers in Tendon Research Conference. The major discussion topics included: (1) the biology of tendon stem/progenitor cells (TSPCs) and the potential of stem cell-based tendon therapy using TSPCs and other types of stem cells, namely, embryonic and/or induced pluripotent stem cells (iPSCs), (2) the biological concept and potential impact of cellular senescence on tendon aging, tendon injury repair and the development of degenerative disease, and (3) the effects of tendon cells' mechano-response on tendon cell fate and metabolism. For each topic, a brief overview is presented which summarizes the major points discussed by the group participants. The focus of the discussions ranged from current research progress, challenges and opportunities, to future directions on these topics. In the preparation of this manuscript, authors consulted relevant references as a part of their efforts to present an accurate view on the topics discussed.

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Citations

Oct 6, 2016·Annals of the New York Academy of Sciences·Daniel J Leong, Hui B Sun
Mar 21, 2018·Connective Tissue Research·Arash MehdizadehDavid W Smith
Sep 4, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jared L Zitnay, Jeffrey A Weiss
Aug 22, 2018·Journal of Tissue Engineering·Ryo ToriiVivek Mudera

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