Biology and pathology of nectins and nectin-like molecules

Current Opinion in Cell Biology
Toshiaki Sakisaka, Yoshimi Takai

Abstract

Immunoglobulin-like nectins contribute to the formation of a variety of cell-cell junctions, acting cooperatively with, or independently of, cadherins. In addition, nectins heterophilically trans-interact with nectin-like molecules (Necls), which are involved in cell adhesion, migration, and proliferation, and assist or modify their functions. On the other hand, nectins and Necls serve as viral receptors and are associated with human diseases (including cancer) when mutated or upregulated.

References

Dec 11, 1996·International Journal of Cancer. Journal International Du Cancer·C ChadéneauM G Denis
Jul 31, 1998·Molecular Immunology·M S Freistadt, K E Eberle
Jun 17, 1999·Trends in Cell Biology·S Tsukita, M Furuse
Oct 6, 1999·Current Opinion in Cell Biology·S TsukitaM Itoh
Jan 12, 2001·Physiological Reviews·Y TakaiT Matozaki
Mar 30, 2001·Nature Genetics·M KuramochiY Murakami
Apr 3, 2001·Nature Reviews. Molecular Cell Biology·S TsukitaM Itoh
Feb 6, 2002·The Journal of Cell Biology·Akira MizoguchiYoshimi Takai
Jun 7, 2002·The Journal of Biological Chemistry·Mari MasudaYoshinori Murakami
Jul 18, 2002·Current Biology : CB·Kumi Ozaki-KurodaYoshimi Takai
Jul 27, 2002·Annual Review of Microbiology·James M Hogle
Aug 31, 2002·Science·Thomas BiedererThomas C Südhof
Oct 2, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Atsunori FukuharaYoshimi Takai
Nov 26, 2002·The Journal of Biological Chemistry·Masanori AsadaYoshimi Takai
Nov 29, 2002·Journal of Cell Science·Yoshimi Takai, Hiroyuki Nakanishi
Jan 1, 2003·The Journal of Cell Biology·Alpha S Yap, Eva M Kovacs
Jun 6, 2003·Biochemical and Biophysical Research Communications·Tomoyuki HondaYoshimi Takai
Aug 13, 2003·The Journal of Experimental Medicine·Cristina BottinoAlessandro Moretta
Sep 13, 2003·Journal of Virology·Patricia G Spear, Richard Longnecker

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Citations

Mar 28, 2008·Histochemistry and Cell Biology·Klaus Ebnet
Jun 15, 2006·Amino Acids·M Gruber-OlipitzG Lubec
Aug 21, 2012·Nature Structural & Molecular Biology·Oliver J HarrisonLawrence Shapiro
Mar 30, 2010·Médecine sciences : M/S·Gaëlle FournierMarc Lopez
Feb 18, 2011·The Journal of Biological Chemistry·Hirotaka NaritaToshiaki Sakisaka
Jul 11, 2006·Genome Research·Cosmas GiallourakisRamnik Xavier
May 17, 2008·Pharmacological Reviews·Dolores D MrukC Yan Cheng
Feb 1, 2008·Journal of Virology·Mark G DelboyAnthony V Nicola
Sep 8, 2007·American Journal of Nephrology·Jun Miyoshi, Yoshimi Takai
Dec 18, 2013·Immunology and Cell Biology·Lucas Ferrari de AndradeLudovic Martinet
Aug 19, 2007·The Journal of Cell Biology·Claire Q F Wang, C Yan Cheng
Jul 18, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M KarabulutN F Aykan
Jun 15, 2011·International Journal of Hygiene and Environmental Health·Timo R HammerDirk Hoefer
Oct 21, 2010·American Journal of Clinical Pathology·Melissa S DeryckeAmy P N Skubitz
Nov 19, 2015·Molecular Oncology·Anna ŚledzińskaSergio A Quezada
Oct 19, 2007·Current Opinion in Cell Biology·Toshiaki SakisakaYoshimi Takai
Feb 7, 2009·European Journal of Immunology·Kent S BolesMarco Colonna
Aug 23, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Maiko InagakiYoshimi Takai
Feb 14, 2013·Journal of Neuroscience Research·Elizabeth D ButtermoreManzoor A Bhat
Oct 10, 2006·Experimental Cell Research·Kiyo HiramotoHironori Katoh
Aug 17, 2005·Current Opinion in Cell Biology·Sandra SousaPascale Cossart
Jul 19, 2005·Cytokine & Growth Factor Reviews·Weiliang XiaC Yan Cheng
Apr 6, 2006·Journal of Biochemistry and Molecular Biology·Shigetomo FukuhraNaoki Mochizuki
Apr 18, 2009·Cell Adhesion & Migration·Hideru TogashiYoshimi Takai
Mar 7, 2015·Nature Reviews. Immunology·Ludovic Martinet, Mark J Smyth
Nov 22, 2014·Frontiers in Cellular and Infection Microbiology·Jennifer V HallRobert V Schoborg
Oct 20, 2014·Cellular and Molecular Life Sciences : CMLS·Dibyendu Samanta, Steven C Almo
Jul 26, 2016·Frontiers in Immunology·Katharina Pallmer, Annette Oxenius

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