Biology and therapeutic potential of adult retinal stem cells

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Brian G Ballios, Derek van der Kooy

Abstract

Retinal degeneration encompasses a constellation of common pathologies for which there is no regenerative treatment. Vision loss has a devastating impact on quality of life and activities of daily living. Pharmacologic treatments serve to stave off disease progression but do not represent a restorative approach. Cellular transplantation is considered to be a promising approach for future therapy for retinal degeneration. There are, however, significant barriers that must be overcome if cell transplantation is to become a clinical reality. In this review, we focus on the need for a cellular replacement therapy for retinal disease and the promise of stem cells as candidate cellular therapeutics. In particular, we discuss the origins of stem cells in the retina, the discovery and characterization of retinal stem cells isolated from adult humans, and their transplantation potential and clinical implications.

References

Jul 1, 1989·Developmental Biology·C M Park, M J Hollenberg
Jun 1, 1985·The Anatomical Record·R W Young
Jan 1, 1993·International Review of Cytology·C M Park, M J Hollenberg
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C Lois, A Alvarez-Buylla
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·C L CepkoD Ezzeddine
Sep 1, 1996·Trends in Neurosciences·S WeissD van der Kooy
Apr 4, 1997·Science·R McKay
Dec 23, 1998·Survey of Ophthalmology·P LeeA P Adamis
Mar 18, 1999·Ophthalmology·E L Berson, F A Jakobiec
Nov 2, 1999·European Journal of Ophthalmology·P V AlgvereE Dafgård Kopp
Dec 2, 1999·Nature Genetics·T FurukawaC L Cepko
Mar 17, 2000·Science·V TropepeD van der Kooy
Feb 7, 2001·Biochemical and Biophysical Research Communications·I AhmadH Pham
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·P D CalvertJ Lem
Apr 2, 2003·Vision Research·Deborah C Otteson, Peter F Hitchcock
Jul 8, 2003·Nature Neuroscience·Reiko KinouchiDong Feng Chen
Oct 16, 2003·JAMA : the Journal of the American Medical Association·Nathan G CongdonThomas Lietman
Nov 20, 2003·Nature Neuroscience·Akihiro NishidaTakahisa Furukawa
Apr 20, 2004·Progress in Retinal and Eye Research·Henry KlassenMichael J Young
Oct 27, 2004·Investigative Ophthalmology & Visual Science·Henry J KlassenMichael J Young
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Brenda L K ColesDerek van der Kooy
Nov 24, 2004·Investigative Ophthalmology & Visual Science·Glen T PruskyRobert M Douglas
Jan 14, 2005·The Journal of Biological Chemistry·Kimberley M DorvalRod Bremner
May 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hans S KeirsteadOswald Steward
Jun 1, 2005·The British Journal of Ophthalmology·G B ArdenR O Schlingemann
Jun 7, 2005·Expert Opinion on Emerging Drugs·Grant M Comer, Thomas A Ciulla
Dec 6, 2005·Experimental Eye Research·P Elizabeth RakoczyJohn R Heckenlively
Feb 17, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Michael J Young
Mar 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Izzy Livne-BarRod Bremner
Apr 4, 2006·Progress in Retinal and Eye Research·R E Hogg, U Chakravarthy
Jul 1, 2006·Nature·David T Scadden
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Deepak A LambaThomas A Reh
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group

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Citations

Dec 31, 2011·Stem Cell Research & Therapy·Rubens Camargo Siqueira
Apr 9, 2011·Stem Cell Reviews and Reports·Peter McColganPaul Bentley
Jun 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Małgorzata NitaUrszula Mazurek
Aug 3, 2010·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Phil Hooper
Jun 3, 2015·Stem Cells Translational Medicine·Zala LužnikStefano Ferrari
Jul 26, 2011·Journal of Biomaterials Science. Polymer Edition·Sophie CaiMichael Joseph Young

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