Biology and treatment of acute lymphoblastic leukemia

Hematology/oncology Clinics of North America
Rob Pieters, William L Carroll

Abstract

Acute lymphoblastic leukemia (ALL), the most common type of cancer in children, is a heterogeneous disease in which many genetic lesions result in the development of multiple biologic subtypes. Today, with intensive multiagent chemotherapy, most children who have ALL are cured. The many national or institutional ALL therapy protocols in use tend to stratify patients in a multitude of different ways to tailor treatment to the rate of relapse. This article discusses the factors used in risk stratification and the treatment of pediatric ALL.

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Citations

Jan 23, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Aydan ÇankalHale Ören
May 2, 2013·Haematologica·Christian Michel Zwaan, Richard Sposto
Jan 17, 2013·Revista brasileira de hematologia e hemoterapia·Camila Silva Peres CancelaBenigna Maria de Oliveira
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Nov 26, 2010·Pediatric Blood & Cancer·Rejane de Souza ReisMaria S Pombo-de-Oliveira
Oct 12, 2014·Revista brasileira de hematologia e hemoterapia·Gisele Moledo de VasconcelosMaria S Pombo-de-Oliveira
Jul 20, 2011·Leukemia Research·Silvia SorianiClara Cesana
Oct 1, 2014·Oncology Nursing Forum·Ellyn E MatthewsNancy King
Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rob PietersJacques Van Dongen
Mar 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tomasz SzczepanskiJacques J M van Dongen
Apr 29, 2021·Blood and Lymphatic Cancer : Targets and Therapy·Cynthia BenderAnupam Verma

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