Biology and treatment of renal tumours in childhood

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Jesper BrokKathy Pritchard-Jones

Abstract

In Europe, almost 1000 children are diagnosed with a malignant renal tumour each year. The vast majority of cases are nephroblastoma, also known as Wilms' tumour (WT). Most children are treated according to Société Internationale d'Oncologie Pédiatrique Renal Tumour Study Group (SIOP-RTSG) protocols with pre-operative chemotherapy, surgery, and post-operative treatment dependent on stage and histology. Overall survival approaches 90%, but a subgroup of WT, with high-risk histology and/or relapsed disease, still have a much poorer prognosis. Outcome is similarly poor for the rare non-WT, particularly for malignant rhabdoid tumour of the kidney, metastatic clear cell sarcoma of the kidney (CCSK), and metastatic renal cell carcinoma (RCC). Improving outcome and long-term quality of life requires more accurate risk stratification through biological insights. Biomarkers are also needed to signpost potential targeted therapies for high-risk subgroups. Our understanding of Wilms' tumourigenesis is evolving and several signalling pathways, microRNA processing and epigenetics are now known to play pivotal roles. Most rhabdoid tumours display somatic and/or germline mutations in the SMARCB1 gene, whereas CCSK and paediatric RCC reveal a ...Continue Reading

Citations

Oct 27, 2017·Nature Reviews. Urology·William Mifsud, Kathy Pritchard-Jones
Nov 2, 2017·Nature Reviews. Urology·Marry M van den Heuvel-EibrinkUNKNOWN International Society of Paediatric Oncology — Renal Tumour Study Group (SIOP–RTSG)
Feb 15, 2019·Pediatric Blood & Cancer·Thomas J JacksonUNKNOWN Children's Cancer and Leukaemia Group (CCLG) Renal Tumours Group
Mar 14, 2019·Pediatric Blood & Cancer·Simone CesaroGianni Bisogno
Sep 10, 2019·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Guanghua CheYunfeng Zhang
May 5, 2020·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Colin KennyMaureen J O'Sullivan
Sep 2, 2020·Pediatric Blood & Cancer·Satyajit RayDermot Murphy
Oct 31, 2018·Children·Hannah M PhelpsHarold N Lovvorn
Jan 30, 2020·Revista da Associação Médica Brasileira·Bruna M de Sá PereiraMariana Maschietto
Jun 18, 2017·F1000Research·Roberto I Lopes, Armando Lorenzo
Jan 4, 2019·Paediatric Drugs·Radna Minou Oostveen, Kathy Pritchard-Jones
Oct 23, 2019·Journal of Oncology·Tongyi LuJing He
Sep 10, 2020·International Journal of Cancer. Journal International Du Cancer·Kayo NakataUNKNOWN IICC-3 Contributors
Feb 2, 2019·Nature Reviews. Nephrology·Taryn Dora TregerSam Behjati
Mar 13, 2020·Nature Communications·Camilla CalandriniJarno Drost
Sep 27, 2018·Case Reports in Pediatrics·Audrey PetitHervé Sartelet
Jun 2, 2018·Annals of Biomedical Engineering·Tania K MorimotoAllison M Okamura
Jan 17, 2019·PeerJ·Sanja Radojević-ŠkodrićSnežana Pejić
Dec 11, 2019·Biomolecules·Melissa Quintero EscobarLjubica Tasic
Nov 28, 2020·International Urology and Nephrology·Ying ZhangCheng-Ru Huang
Jul 22, 2017·Molecular Cancer Therapeutics·Ela MarkovskyRonit Satchi-Fainaro
Jan 19, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sophie C HuijskensGeert O Janssens
Dec 21, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jesper BrokFilippo Spreafico
Dec 15, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joeri MulGeert O Janssens
Dec 3, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F GuerreiroC Kontaxis
Apr 13, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Joeri MulGeert O Janssens
Jul 3, 2021·Cancers·Alissa GroenendijkAnnelies M C Mavinkurve-Groothuis
Aug 8, 2021·Journal of Magnetic Resonance Imaging : JMRI·Justine N van der BeekAnnemieke S Littooij
Aug 14, 2021·Technology in Cancer Research & Treatment·Wang LiLi Haisha
Oct 16, 2021·Nature Reviews. Disease Primers·Filippo SpreaficoKathy Pritchard-Jones

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Related Papers

Nature Reviews. Urology
SIOP Renal Tumour Study Group
Pediatric Radiology
Anne M Smets, Jan de Kraker
Cancer Chemotherapy and Pharmacology
David J Reeves, Chin Y Liu
© 2021 Meta ULC. All rights reserved