PMID: 8597383Dec 29, 1995Paper

Biology of bone marrow stroma

Annals of the New York Academy of Sciences
B R Clark, A Keating

Abstract

The marrow microenvironment is a complex, three-dimensional structure composed of many cell types and abundant extracellular matrix. Much of the data are derived from analysis of the adherent layer of murine and, especially, human long-term marrow cultures. An essential feature of this in vitro counterpart to the marrow microenvironment is the presence of flat angulated cells functionally defined as marrow stromal cells with the following phenotype: type IV collagen(+), laminin(+), vimentin(+), CD10(+), muscle actin(+), Stro-1(+), and negative for CD45, Mac-1, and HLA-DR. Stromal precursors are Stro-1(+) and CD34(+). Regulation of hematopoietic precursors by the microenvironment occurs by elaboration of regulatory molecules such as hematopoietic cytokines, by cell-cell contact via adhesion molecules such as alpha 4 beta 1 integrin, and by interactions with components of the extracellular matrix as in the case of the glycosaminoglycan hyaluronic acid with cell-associated CD44. Although little about the regulation of stromal cell development itself is known, several studies indicate the transplantability of marrow stromal cells under specific conditions. These developments suggest a potential role of stromal cells in cell therapy...Continue Reading

References

Jun 1, 1977·Journal of Cellular Physiology·T M DexterL G Lajtha
Oct 1, 1979·The Journal of Experimental Medicine·H Westen, D F Bainton
Jul 1, 1992·Baillière's Clinical Haematology·B I Lord
Jul 1, 1992·Baillière's Clinical Haematology·P W Kincade
Feb 1, 1992·Current Opinion in Immunology·S GordonS Clarke
Aug 1, 1992·The Journal of Clinical Investigation·J TeixidóP Anklesaria
Jul 1, 1992·Baillière's Clinical Haematology·B R ClarkT M Dexter
Jan 1, 1991·Journal of Perinatal Medicine·R D JelsemaR J Sokol
Jun 1, 1991·The Journal of Cell Biology·C Nathan, M Sporn
Apr 1, 1990·American Journal of Infection Control·W A Rutala
May 1, 1990·The Journal of Experimental Medicine·G Van ZantJ J Chen
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H J SutherlandC J Eaves
Jan 1, 1990·Molecular and Cellular Biology·R D OwenM C Ostrowski
Feb 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P AnklesariaJ S Greenberger
Mar 1, 1986·Journal of the American Academy of Dermatology·D A Weigand
Aug 1, 1987·Journal of Microscopy·T D Allen
Jan 1, 1985·Advances in Alcohol & Substance Abuse·D W BrookB Stimmel
Jun 1, 1983·British Journal of Haematology·A H PiersmaK G Brockbank
Sep 1, 1983·American Journal of Hematology·M Tavassoli, A Friedenstein
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S Gartner, H S Kaplan
Jan 1, 1982·Journal of Cellular Physiology. Supplement·T M Dexter

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Citations

Jul 13, 2002·The Journal of Pathology·Richard PoulsomNicholas A Wright
May 15, 2002·Leukemia Research·H Joachim Deeg
Jan 27, 2000·Immunopharmacology·I Guest, J Uetrecht
Jul 17, 1999·Trends in Neurosciences·B SchefflerD A Steindler
Sep 16, 2000·Experimental Hematology·R J Deans, A B Moseley
Dec 26, 2001·Experimental Hematology·G G WulfM A Goodell
Jul 24, 2002·Experimental Hematology·Nadia QuiriciGiorgio Lambertenghi Deliliers
Sep 7, 2000·International Journal of Radiation Oncology, Biology, Physics·A A JohnssonI Turesson
Feb 6, 2004·Maturitas·Marco GambaccianiChristian Wüster
Mar 29, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gerold HolzerRobert J Majeska
Jul 3, 2003·Epilepsy Research·Rekha BhattAllan Siegel
Feb 16, 2010·Nature Reviews. Immunology·Koji TokoyodaAndreas Radbruch
Feb 1, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Chou Chai, Kam W Leong
Oct 3, 2002·British Journal of Haematology·Ulrich SilerGerd Klein
Mar 12, 2002·Tissue Engineering·Alexander S KrupnickAlan W Flake
Jan 16, 2002·Cancer Biotherapy & Radiopharmaceuticals·C HicksR Lindeman
Sep 12, 2000·Journal of Hematotherapy & Stem Cell Research·E A Frolova-JonesD M Meredith
Mar 4, 2005·Surgical Infections·Rodrigo B FonsecaDavid H Livingston
May 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M GalloN Normanno
Jun 27, 2003·Journal of Pediatric Orthopedics·Eng Hin Lee, James H P Hui
Jun 11, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Martine M L DeckersClemens W G M Löwik
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·D C ColterD J Prockop
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·R F PereiraD J Prockop

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