Biology of gastrointestinal stromal tumors

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christopher L CorlessMichael C Heinrich

Abstract

Once a poorly defined pathologic oddity, in recent years, gastrointestinal stromal tumor (GIST) has emerged as a distinct oncogenetic entity that is now center stage in clinical trials of kinase-targeted therapies. This review charts the rapid progress that has established GIST as a model for understanding the role of oncogenic kinase mutations in human tumorigenesis. Approximately 80% to 85% of GISTs harbor activating mutations of the KIT tyrosine kinase. In a series of 322 GISTs (including 140 previously published cases) studied by the authors in detail, mutations in the KIT gene occurred with decreasing frequency in exons 11 (66.1%), 9 (13%), 13 (1.2%), and 17 (0.6%). In the same series, a subset of tumors had mutations in the KIT-related kinase gene PDGF receptor alpha (PDGFRA), which occurred in either exon 18 (5.6%) or 12 (1.5%). The remainder of GISTs (12%) were wild type for both KIT and PDGFRA. Comparative studies of KIT-mutant, PDGFRA-mutant, and wild-type GISTs indicate that there are many similarities between these groups of tumors but also important differences. In particular, the responsiveness of GISTs to treatment with the kinase inhibitor imatinib varies substantially depending on the exonic location of the KIT...Continue Reading

References

Jul 1, 1992·Human Pathology·S Haque, P J Dean
Feb 1, 1992·The American Journal of Surgical Pathology·P N CooperM F Dixon
Sep 1, 1983·The American Journal of Surgical Pathology·M T Mazur, H B Clark
Feb 1, 1995·The American Journal of Surgical Pathology·M Miettinen Maarit-Sarlomo-Rikala
Jan 1, 1995·American Journal of Clinical Pathology·D W Franquemont
Sep 1, 1994·Postgraduate Medical Journal·M el-OmarR Thompson
Mar 1, 1996·The American Journal of Surgical Pathology·T W ShekL Ma
Apr 1, 1997·The American Journal of Surgical Pathology·J A Brainard, J R Goldblum
Oct 13, 1998·Virchows Archiv : an International Journal of Pathology·M MiettinenA J Kovatich
Jan 15, 1999·The American Journal of Surgical Pathology·T S EmoryT J O'Leary
Feb 16, 1999·The American Journal of Surgical Pathology·P O'BrienA Gnidec
Jun 11, 1999·The American Journal of Pathology·Q TianC A Moskaluk
Aug 6, 1999·The American Journal of Surgical Pathology·J A TworekH D Appelman
Aug 6, 1999·The American Journal of Surgical Pathology·J A TworekH D Appelman
Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·N G KimH Kim
Mar 7, 2000·The American Journal of Pathology·M L LuxJ A Fletcher
May 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·J D ReithS W Weiss
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B E PlaatW T van der Graaf
Oct 7, 2000·The American Journal of Surgical Pathology·C Ortiz-HidalgoJ Albores-Saavedra
Oct 26, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M MiettinenM Sarlomo-Rikala
Nov 14, 2000·The American Journal of Pathology·K IsozakiJ M Vanderwinden

❮ Previous
Next ❯

Citations

Apr 1, 2005·Pathology Oncology Research : POR·Zsolt OroszZoltán Sápi
Jul 12, 2005·Der Internist·K Spiekermann, W Hiddemann
Sep 1, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Harri SihtoHeikki Joensuu
Apr 1, 2005·Pediatric Radiology·Alexia EgloffJohanne E Dillon
Mar 20, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Sandip Basu
Jan 5, 2006·Annals of Hematology·Michael A Morgan, Christoph W M Reuter
Dec 9, 2010·Cancer Chemotherapy and Pharmacology·Suzanne George, Jonathan C Trent
Mar 19, 2013·Cancer Chemotherapy and Pharmacology·Shreyaskumar Patel
Sep 4, 2009·Pediatric Surgery International·Maureen J O'Sullivan
Dec 8, 2007·Journal of Cancer Research and Clinical Oncology·L DovaN Pavlidis
Jul 31, 2007·Surgical Endoscopy·Sanjoy BasuNick Davies
Sep 7, 2005·Journal of Gastroenterology·Yasuhisa ShinomuraSeiichi Hirota
Feb 3, 2011·Journal of Gastroenterology·Isabelle HosteinJean-Michel Coindre
Nov 22, 2007·Surgery Today·Masaji HashimotoHiroshi Hashimoto
Sep 5, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hiroshi YasuiAkio Yanagisawa
Oct 9, 2007·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Salah-Eddin Al-BatranElke Jäger
May 16, 2006·Journal of Cutaneous Medicine and Surgery·Manisha LambaTerence Moyana
Aug 22, 2009·Wiener medizinische Wochenschrift·Ferdinand PlonerUNKNOWN für das österreichische GIST-Panel
Mar 20, 2013·Wiener medizinische Wochenschrift·Evelyne BareckUNKNOWN Austrian representatives of Medical and Surgical Oncology, Pathology, Radiology, Nuclear Medicine, Gastroenterology, and Lab
Jan 30, 2010·Cancer Metastasis Reviews·Georgios S Papaetis, Kostas N Syrigos
Feb 3, 2007·Digestive Diseases and Sciences·Mark TestrooteSteven Rhemrev
Dec 17, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Mona-Elisabeth RevheimTherese Seierstad
Apr 4, 2009·Targeted Oncology·Florence Duffaud, Axel Le Cesne
Apr 3, 2010·Targeted Oncology·Philippe A Cassier, Jean-Yves Blay
Jun 12, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mehrdad NikfarjamKevin F Staveley-O'Carroll
Mar 18, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ying-Yong HouAndrea Frilling
Jan 29, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Song ZhengYue-long Pan
Feb 22, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nikolaos VassosRoland S Croner
Oct 26, 2005·Current Treatment Options in Oncology·Chi Tarn, Andrew K Godwin
Feb 10, 2007·Current Oncology Reports·Nancy L Lewis
Jun 26, 2007·Current Oncology Reports·Alexander J F LazarDina Lev
Sep 10, 2008·Current Oncology Reports·Peter Reichardt
Jun 3, 2011·Current Oncology Reports·Sherif S Morgan, Lee D Cranmer
May 11, 2013·Current Oncology Reports·Ashley E FrithBrian A Van Tine
Nov 7, 2009·Journal of Gastrointestinal Cancer·Georgia DedemadiConstantinos Christopoulos
Jun 2, 2010·Journal of Gastrointestinal Cancer·Guy D Eslick, Jamshid S Kalantar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Michael C HeinrichJonathan A Fletcher
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christopher L CorlessMichael C Heinrich
© 2021 Meta ULC. All rights reserved