PMID: 9430164Jan 16, 1998Paper

Biology of HIV-1 in women and men

Obstetrics and Gynecology Clinics of North America
H Burger, B Weiser

Abstract

The 1990s have been marked by tremendous progress in understanding HIV-1 infection and disease progression in infected individuals. The new discoveries have direct applications in predicting clinical outcomes and monitoring antiviral therapies. With the identification of secondary receptors for HIV-1 cell entry, the CCR-5 receptor was found to be a single genetically determined factor influencing both HIV-1 transmission and disease progression. Quantitation of HIV-1 RNA led to the discoveries that detectable or even high levels of HIV-1 replication occur during all phases of infection, and that plasma HIV-1 RNA levels are powerful predictors of clinical outcome. These findings have increased the ability to predict disease progression and to monitor-antiviral therapy in infected individuals.

References

Apr 1, 1991·The Journal of Clinical Investigation·C E MackewiczJ A Levy
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H BurgerR A Gibbs
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B WeiserH Burger
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D J EilbottB Weiser

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