Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
L Gutiérrez-González, N A Wright

Abstract

This review concentrates on one main aspect of cancerization in the oesophagus and stomach: principally, intestinal metaplasia. There are at least two other important pathways that lead to cancer and do not need such a morphological transformation. One is the gastric type of carcinoma on the Lauren classification, which arises directly from the stem cell zone and is the signet ring form of cancer, while the other is spasmolytic polypeptide-expressing metaplasia (SPEM)--spasmolytic polypeptide (TFF2) expressing metaplasia, where the gastric glands become filled with TFF2-expressing cells and may also lead to gastric dysplasia and cancer. The development of intestinal metaplasia is complex. Here, we examine intestinal metaplasia in molecular terms, noting the over-expression of Cdx1, Cdx2, Pdx1, Oct1, TFF3 and the downregulation of Hedgehog signalling; Runx3 is deactivated by epigenetic silencing, and pathways such as Wnt and MARK/ERK are involved. These changes start to explain the principles of the development of intestinal metaplasia and suggest that the regulation of these genes is of importance in the development of gastric cancer.

References

Jun 8, 1979·Journal of Cancer Research and Clinical Oncology·K SasajimaT Sugimura
Feb 1, 1992·Molecular and Cellular Biology·C P VerrijzerP C van der Vliet
Nov 1, 1994·Molecular and Cellular Biology·E SuhP G Traber
Oct 1, 1993·Japanese Journal of Cancer Research : Gann·H WatanabeA Ito
Mar 1, 1993·Journal of Clinical Pathology·G M SobalaM F Dixon
Feb 1, 1996·Molecular and Cellular Biology·E Suh, P G Traber
Mar 1, 1996·European Journal of Biochemistry·F DrummondY H Edwards
Mar 6, 1997·Nature·K ChawengsaksophakF Beck
May 15, 1997·Genes & Development·A K Ryan, M G Rosenfeld
Jun 1, 1997·Current Opinion in Genetics & Development·L H Pevny, R Lovell-Badge
Jun 20, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A OsterL I Larsson
Jun 17, 1998·Genes & Development·M HebrokD A Melton
Dec 22, 1998·Mechanisms of Development·J MotoyamaC Hui
Jan 28, 1999·Differentiation; Research in Biological Diversity·V SubramanianG S Evans
May 14, 1999·Gut·W M WongN A Wright
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·F BeckJ B Furness
Jul 29, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J E TingstedtL I Larsson
Jan 11, 2000·International Journal of Cancer. Journal International Du Cancer·I A ScotiniotisS J Shiff
Jan 11, 2002·Developmental Biology·P PrinosD Lohnes
Feb 16, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·T MizoshitaM Tatematsu
Jun 8, 2002·Biochemical and Biophysical Research Communications·Hiroyuki MutohKentaro Sugano

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Citations

Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yumiko FujiiMasanori Hatakeyama
Dec 8, 2011·World Journal of Gastroenterology : WJG·Massimo RuggeDavid Y Graham
May 1, 2012·Pathology, Research and Practice·A PoehlmannA Roessner
Apr 7, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Massimo RuggeUNKNOWN Società Italiana di Anatomia Patologica e Citopatologia Diagnostica/International Academy of Pathology, Italian division (SI
Apr 15, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Rugge
Sep 17, 2010·Biology of the Cell·Timothy J UnderwoodJeremy P Blaydes
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carol W M ChanWalter F Bodmer
Apr 7, 2010·The American Journal of Pathology·Lina UddTomi P Mäkelä
Dec 25, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C DuarteA E Silva
May 17, 2018·Genetics and Molecular Biology·Danilo do Rosário PinheiroBarbara do Nascimento Borges
Sep 4, 2009·Virchows Archiv : an International Journal of Pathology·Warner Alpízar-AlpízarBoye Schnack Nielsen
Mar 6, 2010·The American Journal of Gastroenterology·Pelayo CorreaKeith T Wilson
Sep 2, 2017·Nature Reviews. Cancer·Veronique Giroux, Anil K Rustgi
Mar 1, 2012·Gut and Liver·Byoung Hwan LeeIn Sung Song
Oct 17, 2014·World Journal of Gastroenterology : WJG·Debora CompareGerardo Nardone
Jun 28, 2018·F1000Research·William WaddinghamMarnix Jansen
Jun 19, 2018·Scandinavian Journal of Gastroenterology·Liming ZhangGuijian Feng
Apr 30, 2017·Cancer Biomarkers : Section a of Disease Markers·Boram ChoiHan-Kwang Yang
Jan 18, 2012·Oncotarget·Giulia PiazziLuigi Ricciardiello

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