Biology of mast cell tryptase. An inflammatory mediator

The FEBS Journal
Jenny Hallgren, Gunnar Pejler

Abstract

In 1960, a trypsin-like activity was found in mast cells [Glenner GG & Cohen LA (1960) Nature 185, 846-847] and this activity is now commonly referred to as 'tryptase'. Over the years, much knowledge about mast cell tryptase has been gathered, and a recent (18 January 2006) PubMed search for the keywords 'tryptase + mast cell*' retrieved 1661 articles. However, still very little is known about its true biological function. For example, the true physiological substrate(s) for mast cell tryptase has not been identified, and the potential role of tryptase in mast cell-related disease is not understood. Mast cell tryptase has several unique features, with perhaps the most remarkable being its organization into a tetrameric state with all of the active sites oriented towards a narrow central pore and its consequent complete resistance towards endogenous macromolecular protease inhibitors. Much effort has been invested to elucidate these properties of tryptase. In this review we summarize the current knowledge of mast cell tryptase, including novel insights into its possible biological functions and mechanisms of regulation.

References

Dec 1, 1979·The Journal of Clinical Investigation·D D MetcalfeK F Austen
Mar 1, 1992·Protein Science : a Publication of the Protein Society·D A Johnson, G J Barton
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H P McNeilR L Stevens
Dec 1, 1992·Journal of Cellular Biochemistry·J LohiJ Keski-Oja
Jan 1, 1990·Archives of Biochemistry and Biophysics·S C AlterL B Schwartz
Jul 1, 1990·American Journal of Respiratory Cell and Molecular Biology·E K Tam, G H Caughey
Aug 1, 1991·The Journal of Clinical Investigation·S J RuossG H Caughey
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P VandersliceG H Caughey
Sep 1, 1990·The Journal of Clinical Investigation·J S MillerL B Schwartz
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S ReynoldsW E Serafin
Oct 1, 1989·The Journal of Clinical Investigation·J S MillerL B Schwartz
May 31, 1985·Biochemical and Biophysical Research Communications·L B SchwartzJ H Griffin
Feb 25, 1984·Journal of Molecular Biology·G von Heijne
May 1, 1980·The Journal of Investigative Dermatology·L B Schwartz, K F Austen
Aug 1, 1995·American Journal of Respiratory Cell and Molecular Biology·J K BrownG H Caughey
Jan 1, 1995·Annals of Neurology·J J RoznieckiT C Theoharides
Jan 1, 1994·Seminars in Thrombosis and Hemostasis·S T Olson, I Björk
May 1, 1994·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·L B Schwartz
May 1, 1994·International Journal of Dermatology·A NaukkarinenM Horsmanheimo
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·R L StevensK F Austen
Mar 31, 1993·Biochemical and Biophysical Research Communications·C M KieltyD Woolley
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·J M ClarkR D Tanaka
Feb 2, 1996·The Journal of Biological Chemistry·J E HuntN Ghildyal
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·J F MolinariW M Abraham
Dec 1, 1995·Journal of Applied Physiology·J F MolinariW M Abraham
Feb 14, 1997·The Journal of Biological Chemistry·M MolinoL F Brass
Jun 1, 1997·The Journal of Clinical Investigation·R J BlairB L Gruber
Feb 1, 1996·Protein Expression and Purification·K SakaiL B Schwartz
Jun 5, 1997·European Journal of Pharmacology·S He, A F Walls
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·K C ElrodR D Tanaka
Sep 18, 1997·The Journal of Clinical Investigation·C U CorveraN W Bunnett
Nov 14, 1997·Physiological Reviews·D D MetcalfeY A Mekori

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Citations

Feb 14, 2013·Acta Neuropathologica·Sofie NelissenSven Hendrix
Jul 5, 2007·Amino Acids·P ChavesF Sánchez-Jiménez
May 27, 2011·Journal of Thrombosis and Thrombolysis·Pancras C WongWilliam A Schumacher
Oct 13, 2009·The Journal of Biological Chemistry·David Pantoja-UcedaChristian P Sommerhoff
Oct 10, 2007·The Journal of Experimental Medicine·Lars A SchneiderHans-Reimer Rodewald
Nov 17, 2007·Antioxidants & Redox Signaling·Joan L ArolasChristian P Sommerhoff
Dec 8, 2009·Biological Reviews of the Cambridge Philosophical Society·Enrico Crivellato, Domenico Ribatti
May 13, 2006·Annual Review of Biophysics and Biomolecular Structure·Meyer B Jackson, Edwin R Chapman
Dec 15, 2007·American Journal of Respiratory Cell and Molecular Biology·Charlotte S MullanLinhua Pang
Nov 26, 2009·American Journal of Respiratory Cell and Molecular Biology·Neil N Trivedi, George H Caughey
Mar 4, 2014·PloS One·Gianni Garcia-FaroldiAnders Lundequist
Apr 2, 2014·Nature Reviews. Urology·Stephen F MurphyPraveen Thumbikat
Apr 16, 2013·BioMed Research International·Agnès FrançoisMarc Benderitter
Oct 17, 2007·Seminars in Immunopathology·Stephen R Holdsworth, Peter G Tipping
Feb 21, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Olaf WendlerBernhard Schick
Nov 6, 2015·International Journal of Molecular Sciences·Min-Kyung JangMyeong Ho Jung
Sep 13, 2015·Cutaneous and Ocular Toxicology·Satoshi YokoyamaKazuya Ooi
Sep 1, 2007·Journal of Cellular and Molecular Medicine·Ken A LindstedtPetri T Kovanen
May 15, 2007·Immunological Reviews·Martin MetzStephen J Galli
May 15, 2007·Immunological Reviews·Odile Malbec, Marc Daëron
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephen T Holgate
Nov 30, 2012·The Journal of Investigative Dermatology·Mi-Sun KimJin Ho Chung
May 27, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Valéria Souza FreitasLélia Batista de Souza
May 31, 2016·International Journal of Molecular Sciences·Soon-Hyo KwonKyoung-Chan Park
Mar 28, 2007·International Immunopharmacology·Runa SurRavi Malaviya
Dec 31, 2009·Human Pathology·María José CarliniLilia Susana Lauría de Cidre
Oct 27, 2009·Journal of Molecular Biology·Christian P SommerhoffHarald Kolmar
Oct 24, 2007·Current Opinion in Immunology·Harsha H Kariyawasam, Douglas S Robinson
Oct 8, 2016·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Brianne BordesJoseph D Tobias
Apr 5, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D OstertagM Schemann
Jun 21, 2012·Anais Brasileiros De Dermatologia·Paulo Ricardo CriadoCidia Vasconcellos
May 12, 2017·Cell Death & Disease·Gunnar PejlerHelena Öhrvik
Oct 25, 2008·Brazilian Dental Journal·Ana Paula Neutzling GomesAline Marques Ferreira
May 19, 2007·The FEBS Journal·Tsutomu HamuroShintaro Kamei
Apr 3, 2007·Trends in Immunology·Martin Metz, Marcus Maurer
Jun 29, 2017·Immunological Reviews·Yoshinori YamanishiHajime Karasuyama
Dec 23, 2015·International Journal of Molecular Sciences·Anupam AichKalpna Gupta

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