Biology of oligodendrocyte and myelin in the mammalian central nervous system

Physiological Reviews
N Baumann, D Pham-Dinh


Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and astrocytes constitute macroglia. This review deals with the recent progress related to the origin and differentiation of the oligodendrocytes, their relationships to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases. One of the problems in studies of the CNS is to find components, i.e., markers, for the identification of the different cells, in intact tissues or cultures. In recent years, specific biochemical, immunological, and molecular markers have been identified. Many components specific to differentiating oligodendrocytes and to myelin are now available to aid their study. Transgenic mice and spontaneous mutants have led to a better understanding of the targets of specific dys- or demyelinating diseases. The best examples are the studies concerning the effects of the mutations affecting the most abundant protein in the central nervous myelin, the proteolipid protein, which lead to dysmyelinating diseases in animals and human (jimpy mutation and Pelizaeus-Merzbacher disease or spastic paraplegia, respectively). Oligodendrocytes, as astrocytes, are able to respond to chang...Continue Reading


May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·N H SternbergerH D Webster
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G S EisenbarthM Nirenberg
Apr 1, 1979·Neuroscience Letters·A PrivatN Baumann
Sep 15, 1977·The Biochemical Journal·J PieringerR A Pieringer
Sep 1, 1977·The Journal of Heredity·D P Doolittle, K M Schweikart
Oct 1, 1976·The Journal of Comparative Neurology·R P SkoffA Stocks
Dec 1, 1992·Journal of Neurochemistry·B GrimaB Pessac
Feb 1, 1992·Brain Research. Molecular Brain Research·W P BartlettM Williams
Jan 1, 1992·Journal of Neuroscience Research·T BergerH Kettenmann
Sep 1, 1992·Journal of Neuroscience Research·M V GardinierJ M Matthieu
Dec 1, 1992·Journal of Neurocytology·I D DuncanL Brignolo-Holmes
Nov 1, 1991·Journal of Neuroscience Research·P E BraunL Bernier
Jan 1, 1991·Developmental Neuroscience·N BaumannJ C Turpin
Feb 1, 1990·Trends in Neurosciences·J A BlackS G Waxman
May 1, 1990·The Journal of Cell Biology·S M StaugaitisD R Colman
Jul 1, 1990·Neurochemical Research·S E PodusloC H Pak
Mar 1, 1991·The Journal of Membrane Biology·J L PopotA Dautigny
Feb 1, 1991·Neuroreport·D Pham-DinhJ L Nussbaum
Aug 1, 1991·Journal of Neurocytology·T Ichimura, M H Ellisman

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