Biology of oligodendrocyte and myelin in the mammalian central nervous system

Physiological Reviews
N Baumann, D Pham-Dinh

Abstract

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and astrocytes constitute macroglia. This review deals with the recent progress related to the origin and differentiation of the oligodendrocytes, their relationships to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases. One of the problems in studies of the CNS is to find components, i.e., markers, for the identification of the different cells, in intact tissues or cultures. In recent years, specific biochemical, immunological, and molecular markers have been identified. Many components specific to differentiating oligodendrocytes and to myelin are now available to aid their study. Transgenic mice and spontaneous mutants have led to a better understanding of the targets of specific dys- or demyelinating diseases. The best examples are the studies concerning the effects of the mutations affecting the most abundant protein in the central nervous myelin, the proteolipid protein, which lead to dysmyelinating diseases in animals and human (jimpy mutation and Pelizaeus-Merzbacher disease or spastic paraplegia, respectively). Oligodendrocytes, as astrocytes, are able to respond to chang...Continue Reading

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Citations

Feb 28, 2003·Journal of Neuroscience Research·Jaspreet KaurGeorge Harauz
Sep 21, 2004·Journal of Neuroscience Research·Eric BirgbauerMichael Webb
Mar 18, 2005·Journal of Neuroscience Research·L S DeBruinG Harauz
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