Biology of TNFalpha and IL-10, and their imbalance in heart failure.

Heart Failure Reviews
K KaurPawan K Singal

Abstract

Our understanding of the multiple in vivo functions of the proinflammatory cytokine, tumor necrosis factor (TNFalpha), is advancing at a rapid pace. In addition to its antitumor effects, overproduction of TNFalpha provokes tissue injury and organ failure. TNFalpha has also been shown to be cardiodepressant and responsible for various cardiovascular complications. It appears that still much needs to be learned for a full comprehension of the role of TNFalpha in heart biology. Another cytokine, interleukin-10 (IL-10), has been shown to have anti-inflammatory properties. It is suggested to counterbalance many adverse effects of TNFalpha. IL-10 suppresses the production of TNFalpha and many other proinflammatory cytokines. TNFalpha-induced oxidative stress is also known to be mitigated by IL-10. Moreover, improvement in cardiac function after treatment with various drugs is also shown to be associated with an increase in IL-10 content. Based on the data reviewed in here, it is suggested that an optimal balance between IL-10 and TNFalpha may be a new therapeutic strategy for a healthier heart.

References

Aug 1, 1978·British Journal of Cancer·N Matthews
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Jun 1, 1992·Immunology Today·M Howard, A O'Garra
Sep 1, 1992·The Journal of Clinical Investigation·B P GiroirB Beutler
Apr 1, 1992·Critical Care Medicine·S O HeardM P Fink
Jan 1, 1992·Annual Review of Immunology·P Vassalli
Dec 1, 1991·The Journal of Experimental Medicine·C BogdanC Nathan
Aug 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A A VlessisD Trunkey
Oct 1, 1987·Journal of Interferon Research·W FiersF Van Roy
Oct 19, 1989·The New England Journal of Medicine·J E ParrilloD Alling
Jan 1, 1988·Annual Review of Biochemistry·B Beutler, A Cerami
Nov 1, 1995·The Journal of Clinical Investigation·S LacrazJ M Dayer
Jan 1, 1994·DNA Sequence : the Journal of DNA Sequencing and Mapping·C PlatzerM Platzer
Jan 1, 1994·The Journal of Clinical Investigation·Y Levy, J C Brouet
Sep 10, 1993·Cell·L A TartagliaD V Goeddel
Apr 1, 1993·The Journal of Experimental Medicine·M HowardS Menon
Mar 1, 1993·Cellular Immunology·C CastagnoliP M Richiardi
Jun 1, 1993·The Journal of Experimental Medicine·A L MoreiraG Kaplan
May 21, 1993·Cell·B M Spiegelman, G S Hotamisligil
Jun 1, 1995·Journal of Molecular and Cellular Cardiology·J P CleutjensK T Weber
Mar 1, 1996·Immunology Today·T R Mosmann, S Sad

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Citations

Sep 1, 2012·Lasers in Medical Science·Vítor S HentschkePedro Dal Lago
Jan 27, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Carolyn HolladayAbhay Pandit
Apr 13, 2010·Antioxidants & Redox Signaling·Neelam KhaperPawan K Singal
Feb 27, 2013·American Journal of Veterinary Research·Sonja FonfaraPeter D Clegg
Apr 15, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yi-min BaoXing-yu Wang
Feb 14, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Bård LundelandPer Vaagenes
Feb 18, 2017·Journal of Applied Physiology·Petra AlánováFrantišek Kolář
Jul 16, 2011·Journal of Applied Physiology·Ye ChenRichard M McCarron
Aug 20, 2019·Journal of Cardiovascular Pharmacology·Jianling LiYalan Li
Feb 23, 2018·Oncotarget·Linlin ChenLing Zhao
Jun 5, 2018·Heart Failure Reviews·Monika BartekovaNaranjan S Dhalla
Dec 15, 2010·Journal of Cellular and Molecular Medicine·Sabrina GreulichJuergen Eckel
Mar 5, 2021·International Immunopharmacology·Shuwan XuJun Wan
Aug 21, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Lulu AnTao Yan
Mar 31, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S R HofmannC M Hedrich

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