PMID: 8938525Oct 1, 1996Paper

Biology of tumor micrometastasis

Journal of Hematotherapy
A Ahmad, I R Hart

Abstract

Metastasis is the major cause of death in cancer patients. Our understanding of the molecular genetic and biologic events that contribute to tumor cell dissemination has increased considerably over the last decade. It is clear that close anatomic and temporal cooperation between cellular adhesion molecules, extracellular matrix-degrading proteases, and tumor vascularization is an essential component of the metastatic behavior of cancer cells. With this improved understanding have come novel antimetastatic therapies targeting distinct molecules and steps in the metastatic cascade. Here, we review the role of matrix-degrading enzymes, changes in cellular adhesive capacity, and tumor angiogenesis during cancer spread.

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Citations

Jul 16, 1997·Journal of the National Cancer Institute·S B FoxA L Harris
Apr 27, 2002·Seminars in Thoracic and Cardiovascular Surgery·Harvey I Pass
Dec 21, 2010·Archives of Medical Research·Sahar Saad El-Din BessaSafinaz Hamdy El-Shourbagy
Mar 20, 1998·International Journal of Cancer. Journal International Du Cancer·V ZawadzkiM Zöller

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