Biology-oriented synthesis of benzopyrano[3,4-c]pyrrolidines

Bioorganic & Medicinal Chemistry
Marco PotowskiHerbert Waldmann

Abstract

A natural product inspired synthesis of 6,6,5-tricyclic compounds via a silver(I)-catalyzed formal 1,3-dipolar cycloaddition of coumarins with α-iminoesters was developed. The reaction proceeds in a stepwise reaction course under formation of the trans-substituted diastereomer with respect to the 1,3-dipole and shows a broad substrate scope.

References

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Jul 19, 2014·Chemical Communications : Chem Comm·Javier Adrio, Juan C Carretero

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