Bioluminescence imaging of live infected salmonids reveals that the fin bases are the major portal of entry for Novirhabdovirus

Journal of Virology
Abdallah HarmacheMichel Bremont

Abstract

Although Novirhabdovirus viruses, like the Infectious hematopietic necrosis virus (IHNV), have been extensively studied, limited knowledge exists on the route of IHNV entry during natural infection. A recombinant IHNV (rIHNV) expressing the Renilla luciferase gene was generated and used to infect trout. A noninvasive bioluminescence assay was developed so that virus replication in live fish could be followed hours after infection. We provide here evidence that the fin bases are the portal of entry into the fish. Confirmation was brought by the use of a nonpathogenic rIHNV, which was shown to persist in fins for 3 weeks postinfection.

References

May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W W LorenzM J Cormier
Nov 1, 1995·Molecular Microbiology·C H ContagD A Benaron
Feb 14, 1998·Nature Medicine·P R ContagC H Contag
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·S Bhaumik, S S Gambhir
Feb 28, 2002·Journal of Virology·Stéphane BiacchesiMichel Brémont
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Christopher H Contag, Brian D Ross
Jan 25, 2003·Diseases of Aquatic Organisms·Kálmán Molnár
Mar 12, 2003·Genes & Development·Tarik F Massoud, Sanjiv S Gambhir
Apr 15, 2003·Journal of Virology·Susan H Cook, Diane E Griffin
Mar 30, 2004·Journal of Virology·Maria-Isabel ThoulouzeMichel Brémont
Jun 29, 2005·Current Topics in Microbiology and Immunology·M Brémont

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Citations

Mar 8, 2013·Applied Microbiology and Biotechnology·Xiao-Feng LiCheng-Feng Qin
Sep 16, 2011·Fish Physiology and Biochemistry·Chris NobleStephanie Yue Cottee
Apr 16, 2013·Fish & Shellfish Immunology·Eloi R VerrierEdwige Quillet
Jan 21, 2009·Journal of Virology·B CostesA Vanderplasschen
Feb 15, 2011·Veterinary Research·Stéphane Biacchesi
Aug 6, 2011·Veterinary Research·Victor Stalin RajAlain Vanderplasschen
Aug 26, 2011·Veterinary Research·Christian DucrotThierry Pineau
Dec 3, 2010·Emerging Infectious Diseases·Benjamin MichelAlain Vanderplasschen
Aug 29, 2013·Developmental and Comparative Immunology·Bertrand Collet
Nov 26, 2013·Developmental and Comparative Immunology·Carolina AquilinoCarolina Tafalla
Oct 23, 2014·Nature Communications·Luca TacchiIrene Salinas
Oct 1, 2013·Journal of Molecular Biology·Christelle LangevinPierre Boudinot
Sep 13, 2015·Fish & Shellfish Immunology·Amparo Estepa, Julio Coll
Jun 26, 2007·Cellular Microbiology·Martha Hutchens, Gary D Luker
Jun 13, 2013·Environmental Microbiology Reports·J Méndez, J A Guijarro
Jan 31, 2014·Journal of Fish Diseases·M AamelfotK Falk
Oct 20, 2010·FEMS Microbiology Reviews·Nuria AndreuSiouxsie Wiles
May 29, 2014·Trends in Microbiology·Jean-Pierre LevraudPierre Boudinot

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