Bioluminescence Tomography-Guided Radiation Therapy for Preclinical Research

International Journal of Radiation Oncology, Biology, Physics
Bin ZhangJohn Wong

Abstract

In preclinical radiation research, it is challenging to localize soft tissue targets based on cone beam computed tomography (CBCT) guidance. As a more effective method to localize soft tissue targets, we developed an online bioluminescence tomography (BLT) system for small-animal radiation research platform (SARRP). We demonstrated BLT-guided radiation therapy and validated targeting accuracy based on a newly developed reconstruction algorithm. The BLT system was designed to dock with the SARRP for image acquisition and to be detached before radiation delivery. A 3-mirror system was devised to reflect the bioluminescence emitted from the subject to a stationary charge-coupled device (CCD) camera. Multispectral BLT and the incomplete variables truncated conjugate gradient method with a permissible region shrinking strategy were used as the optimization scheme to reconstruct bioluminescent source distributions. To validate BLT targeting accuracy, a small cylindrical light source with high CBCT contrast was placed in a phantom and also in the abdomen of a mouse carcass. The center of mass (CoM) of the source was recovered from BLT and used to guide radiation delivery. The accuracy of the BLT-guided targeting was validated with fil...Continue Reading

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Citations

Sep 10, 2016·The British Journal of Radiology·Bridget F KoontzDirk De Ruysscher
Feb 2, 2019·The British Journal of Radiology·Stefan J van HoofFrank Verhaegen
Nov 19, 2019·International Journal of Radiation Oncology, Biology, Physics·Zijian DengKen Kang-Hsin Wang
Mar 6, 2019·International Journal of Radiation Oncology, Biology, Physics·Ariel E MarciscanoTheodore L DeWeese
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li LiuRalph P Mason
Aug 5, 2021·International Journal of Radiation Oncology, Biology, Physics·Leslie A ParselsMeredith A Morgan
Aug 20, 2021·International Journal of Radiation Oncology, Biology, Physics·Xiangkun XuKen Kang-Hsin Wang

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