Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins

Allergy and Asthma Proceedings
Namjil N TsybikovEli Magen

Abstract

Chronic rhinitis (CR) is characteristically divided into several major clinical phenotypes: allergic rhinitis (AR); nonallergic, noninfectious rhinopathy (NAR); and chronic rhinosinusitis (CRS). CRS has two phenotypic variants: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). An area of growing interest is to identify biologic markers that could assess different aspects of CR phenotypes. The aim of the study was to evaluate four CR biomarkers: endothelin-1 (ET-1), thymus and activation-regulated chemokine (CCL17), neopterin, and α-defensins in subjects with AR, NAR, and CRS. Fifty-one patients with AR, 43 patients with NAR, 46 patients with CRSsNP, 54 patients with CRSwNP, and 40 healthy controls were included. ET-1, TARC/CCL17, neopterin, and α-defensins levels in subjects' serum and nasal secretions (NS) were measured by the enzyme-linked immunosorbent assay. High NS levels of ET-1, TARC/CCL17, and α-defensins were characteristic for CRSwNP, although only high NS levels of neopterin were found in the CRSsNP phenotype. AR phenotype was characterized by high NS levels of ET-1 and TARC/CCL17. In the subjects with NAR, none of these biomarker levels in serum and NS differed from those of healthy controls. CR ...Continue Reading

Citations

Apr 7, 2017·Allergy & Rhinology·Angelo G CorsicoGiorgio Ciprandi
Oct 6, 2018·Allergy·Ibon Eguiluz-GraciaMaria J Torres
Sep 2, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zehra Betul PaksoyTuran Turhan
May 8, 2020·Clinical Reviews in Allergy & Immunology·Tesfaye B MershaGurjit K Khurana Hershey
Apr 16, 2020·Frontiers in Cell and Developmental Biology·Anu Laulajainen-HongistoRobert Kern
Dec 2, 2020·Journal of Personalized Medicine·Michał MichalikMichał J Markuszewski
May 20, 2021·Seminars in Immunopathology·Julien Catherine, Florence Roufosse

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