Abstract
Limited data exists regarding biomarker use to predict left ventricular (LV) reverse remodeling (R2). Our aim was to examine the value of soluble ST2 (ST2), N-terminal-pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), and galectin-3 relative to LV-R2 in systolic heart failure (HF), and to develop a clinical score for LV-R2 prediction. R2 was defined as a) LV ejection fraction (LVEF) increase ≥15%, or b) LVEF increase ≥10% plus reduction of LV end-systolic diameter index ≥20% or LV end-systolic volume ≥40%, for 12 months. We studied 304 patients (79.6% men, mean age 66.1 ± 12.3 years) with baseline LVEF <40%. R2 was observed in 104 patients (34.2%). In univariable logistic regression, factors associated with R2 were age (p=0.02), non-ischemic etiology of HF (p<0.001), NYHA functional class (p=0.02), baseline LVEF (p=0.005), absence of left bundle branch block (LBBB; p=0.002), ST2 (p=0.004), NT-proBNP (p=0.005), and hs-cTnT (p<0.001); HF duration achieved borderline significance (p=0.08). In multivariable analysis, ST2 remained the only biomarker associated with LV-R2. We developed the ST2-R2 score for use in clinical practice for predicting R2; variables included were ST2 <48 ng/mL, non-i...Continue Reading
References
Apr 1, 1997·Journal of the American College of Cardiology·R N DoughtyN Sharpe
Dec 12, 2001·Journal of the American College of Cardiology·J LindenfeldUNKNOWN MOCHA (Multicenter Oral Carvedilol Heart failure Assessment) Investigators
Jul 19, 2002·The New England Journal of Medicine·Alan S MaiselUNKNOWN Breathing Not Properly Multinational Study Investigators
Dec 4, 2002·Circulation·Ellen O WeinbergRichard T Lee
Jun 18, 2004·Heart·N G BellengerUNKNOWN CHRISTMAS Study Steering Committee and Investigators
Sep 8, 2005·Circulation·Cheuk-Man YuJeroen J Bax
May 12, 2007·The Journal of Clinical Investigation·Shoji SanadaRichard T Lee
Jun 3, 2008·European Heart Journal·Luigi Di BiaseAndrea Natale
Aug 13, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Charles DelagardelleDaniel R Wagner
Jan 31, 2009·European Journal of Heart Failure·Milos KubánekJohn G F Cleland
Mar 24, 2010·Archives of Internal Medicine·Pramote PorapakkhamHenry Krum
Jun 15, 2010·Cardiovascular Research·Susana RavassaJavier Díez
Sep 25, 2010·International Journal of Cardiology·Pietro FranciaMassimo Volpe
Nov 6, 2010·European Journal of Heart Failure·Paul W X FoleyFrancisco Leyva
Jan 15, 2011·JACC. Cardiovascular Imaging·Marvin A KonstamJames E Udelson
Mar 26, 2011·Journal of the American College of Cardiology·Marco MerloGianfranco Sinagra
Aug 31, 2011·European Heart Journal·Jean-Claude TardifUNKNOWN SHIFT Investigators
Oct 25, 2011·Journal of the American College of Cardiology·James L JanuzziMarc J Semigran
Nov 18, 2011·European Journal of Heart Failure·Natalia Lopez-AndrèsPatrick Lacolley
Mar 1, 2012·Circulation. Heart Failure·Bonnie KyThomas P Cappola
Apr 10, 2012·The American Journal of Cardiology·Marie FertinChristophe Bauters
Nov 8, 2012·European Journal of Heart Failure·Rory B WeinerJames L Januzzi
Feb 7, 2013·Mayo Clinic Proceedings·Josep LupónAntoni Bayes-Genis
Apr 6, 2013·Journal of Cardiovascular Translational Research·James L Januzzi
Jun 7, 2013·Circulation·UNKNOWN WRITING COMMITTEE MEMBERSUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Jan 24, 2014·PloS One·Josep LupónAntoni Bayes-Genis
Mar 14, 2014·JACC. Heart Failure·Hanna K GagginJames L Januzzi
Citations
Apr 2, 2015·International Journal of Cardiology·Kenan Yalta
Aug 28, 2015·International Journal of Cardiology·Damiano MagrìPiergiuseppe Agostoni
Apr 10, 2016·International Journal of Cardiology·Kenan YaltaErtan Yetkin
Aug 17, 2016·The Canadian Journal of Cardiology·Jonathan BeaudoinQuynh A Truong
Oct 21, 2016·Current Heart Failure Reports·Shweta R Motiwala, Hanna K Gaggin
Feb 17, 2017·European Heart Journal·Antoni Bayes-GenisJavier Díez
Mar 8, 2018·Heart Failure Reviews·Michele CorrealeUNKNOWN Master Program Students on Drug Development for Heart Failure
Dec 19, 2017·European Journal of Heart Failure·Josep Lupón, Antoni Bayés-Genís
Nov 7, 2017·European Journal of Heart Failure·Filippos TriposkiadisJohn Parissis
Jun 15, 2017·Cardiology·Sandra AmorimM Júlia Maciel
Oct 9, 2018·Expert Review of Cardiovascular Therapy·Marco MasèGianfranco Sinagra
Feb 2, 2018·Scientific Reports·Takashige TobitaIssei Komuro
Jun 28, 2020·ESC Heart Failure·Jonathan G HowlettJustin A Ezekowitz
Feb 6, 2020·BioMed Research International·Xi-Ying WangJian Yang
Dec 26, 2016·The International Journal of Cardiovascular Imaging·Sandra AmorimM Júlia Maciel
Oct 26, 2018·Hypertension·Rana GhaliGeorge W Booz
Jan 23, 2021·Current Heart Failure Reports·Andrew Abboud, James L Januzzi
Feb 24, 2021·Journal of cardiology·Kenji MaemuraJunya Ako
Feb 22, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mahnaz SalmaniHossein Imani
May 19, 2021·ESC Heart Failure·Alberto AimoMichele Emdin
May 19, 2021·ESC Heart Failure·Kaiming WangGavin Y Oudit
May 18, 2021·Circulation. Heart Failure·Sean P MurphyJames L Januzzi
Sep 6, 2021·European Journal of Heart Failure·Brenda MouraA Mark Richards
Dec 26, 2021·ESC Heart Failure·Jasneet K DevgunSakima A Smith
Oct 20, 2021··Rajamohan Sura, Sanjeet Kumar