Biomarker development: prudence, risk, and reproducibility

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Edward R Dougherty

Abstract

Is a two-fold approach - preliminary studies based on small samples followed by a large-sample study to check reproducibility - in the search for biomarkers really prudent?

References

Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Feb 13, 2004·Bioinformatics·Ulisses M Braga-Neto, Edward R Dougherty
Feb 22, 2008·EURASIP Journal on Bioinformatics & Systems Biology·Blaise HanczarEdward R Dougherty
Oct 23, 2009·Bioinformatics·Mohammadmahdi R YousefiEdward R Dougherty
Nov 28, 2009·Bioinformatics·Anne-Laure Boulesteix
Dec 23, 2009·BMC Medical Research Methodology·Anne-Laure Boulesteix, Carolin Strobl
Feb 5, 2010·Bioinformatics·Blaise HanczarEdward R Dougherty
May 7, 2011·Bioinformatics·Mohammadmahdi R YousefiEdward R Dougherty
Feb 2, 2012·Current Genomics·Edward R DoughertyUlisses M Braga-Neto

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Citations

Sep 8, 2012·Bioinformatics·Mohammadmahdi R Yousefi, Edward R Dougherty
Aug 21, 2013·EURASIP Journal on Bioinformatics & Systems Biology·Edward R Dougherty, Lori A Dalton
Jul 5, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bertrand Jordan
Nov 13, 2013·EURASIP Journal on Bioinformatics & Systems Biology·Edward R Dougherty
Jul 8, 2016·Scientific Reports·Vlasta KorenkovaPaolo Verderio
Jul 26, 2017·Arthritis Research & Therapy·Nancy J OlsenMarvin J Fritzler

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