Biomarker discordance between primary breast cancer and bone or bone marrow metastases

Japanese Journal of Clinical Oncology
Sayako YudaKenji Tamura

Abstract

Discordance in biomarker expression between primary and metastatic tumor sites has been reported in several studies; yet, few have examined this feature in bone lesions. We retrospectively enrolled patients with breast cancer metastasis to the bone or bone marrow, excluding cases where samples from both the primary and metastatic lesions were not available. Expression patterns of the estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2) and Ki67 were compared in primary tumors and bone or bone marrow lesions. Forty-six patients with a median age of 52 years (range, 34-72 years) were included in the study. Discordant rates of ER, PgR and HER2 were 20%, 46% and 0%, respectively. Physicians usually determined treatment options considering the results of biomarker re-evaluation. It is unlikely that biomarker discordance was related to prior treatment. Biomarker discordance in bone or bone marrow lesions is common in patients with breast cancer. An accurate and thorough analysis of biomarkers and metastatic tumor properties is important for clinical decision-making.

References

Nov 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H MullinkC J Meijer
Aug 1, 1987·Journal of Clinical Pathology·N A AthanasouJ O McGee
Sep 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T KuukasjärviJ Isola
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D GancbergD Larsimont
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Oct 1, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·E AmirM Clemons
Mar 21, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C SimmonsM J Clemons
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Nov 30, 2010·Breast Cancer Research and Treatment·J F HiltonM Clemons
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eitan AmirMark Clemons
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Naoki NiikuraNaoto T Ueno
Jan 23, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tomohiro NogamiShozo Ohsumi
Jun 15, 2013·Cancer Treatment Reviews·Natalie H Turner, Angelo Di Leo
Jul 31, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L MigliettaM Ferrarini
Sep 10, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V GuarneriP F Conte
Oct 12, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L D C HoefnagelP J van Diest
Nov 26, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gaetano AurilioFranco Nolè
Feb 5, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A IeniG Tuccari
Oct 4, 2014·Molecular and Clinical Oncology·Reiki NishimuraNobuyuki Arima
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E SenkusUNKNOWN ESMO Guidelines Committee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.