Biomarker-guided antifungal stewardship policies for patients with invasive candidiasis

Current Medical Mycology
Behnam HonarvarEsmaeil Mortaz

Abstract

Invasive fungal infections (IFIs) are among the life-threatening issues in patients with impaired immune system. High administration of antifungals in these patients imposes a heavy economic burden on the national health system. In addition, despite the usually expensive antifungal regimens, the mortality rate due to fungal infections is still high, resulting in the loss of hundreds of lives per year. Survival rate is an indicator of the success of national healthcare policies. Early diagnosis of IFI is critical because any delays may be fatal. The weakness of the old-fashioned culture-based diagnostic methods lies in their time-consuming laboratory procedures. To overcome this problem, several diagnostic approaches have been developed to facilitate the early diagnosis of invasive candidiasis as the most prevalent IFI. These methods are based on the detection of serologic and molecular footprints. However, nowadays, antibiotic resistance and proper and cost-effective use of antibiotics are given special attention in national healthcare policies. The instructions for controlling these indices have been collected under the name of antibiotic stewardship. The present review study was targeted toward providing insight into novel di...Continue Reading

Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay

Software Mentioned

ASP
CAGTA

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Xia LiuBing Ruan
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
D Farmakiotis, D P Kontoyiannis
Current Medical Research and Opinion
John R Perfect
Enfermedades infecciosas y microbiología clínica
Ignacio GadeaJuan Luis Rodríguez-Tudela
© 2022 Meta ULC. All rights reserved