Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study

The Open Cardiovascular Medicine Journal
Vana KolovouGenovefa Kolovou

Abstract

The influence of biomarkers in human lifespan has been investigated but with no clear results yet. Lipids, Uric Acid (UA), Adiponectin (ADIPOQ), Insulin-like Growth Factor (IGF-1), cholesteryl ester transfer protein (CETP) and angiotensin-converting enzyme (ACE) proteins, as well as CETP, ADIPOQ, insulin-like growth factor binding protein-3 (IGFBP3) and ACE-gene polymorphisms were evaluated in 149 Greek individuals. The Long-Lived Families (LON) (n=84) comprised of 3 generations: long-lived aged ≥90 years (P), offspring (FL1) and their grandchildren (FL2), while the Short-Lived Families (EAD) (n=65) where both parents died <75 years, comprised of 2 generations: middle-aged (FD1) and children (FD2). Serum CETP and IGF-1 levels were lower, whereas AdipoQ concentrations were higher in P compared with FL1 and FL2 members (CETP: p = 0.03 for both comparisons; IGF-1 p < 0.001 for both comparisons and ADIPOQ: p = 0.001 and p = 0.004, respectively). Furthermore, serum triglycerides, UA and glucose concentrations were higher in FD1 compared with FD2 subjects (p=0.001, 0.02 and ≤0.001, respectively). In FD2 and FL2, CETP levels were lower in individuals with B2B2 compared with B1B1 genotype (p=0.007). Additionally, ACE concentrations wer...Continue Reading

References

Jul 4, 2002·Current Medical Research and Opinion·Genovefa KolovouDennis V Cokkinos
Mar 18, 2003·Journal of Lipid Research·S Matthijs Boekholdt, John F Thompson
Oct 16, 2003·JAMA : the Journal of the American Medical Association·Nir BarzilaiAlan R Shuldiner
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Jan 19, 2005·Acta Physiologica Scandinavica·F GiorginoJ W Eriksson
Jun 8, 2007·Nature·UNKNOWN NCI-NHGRI Working Group on Replication in Association StudiesFrancis S Collins
May 31, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gil AtzmonNir Barzilai
Apr 10, 2009·Current Drug Targets·Konstantinos TziomalosDimitri P Mikhailidis
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Xuefen SuRulla M Tamimi
Oct 20, 2009·Current Medicinal Chemistry·G D KolovouD P Mikhailidis
Mar 11, 2011·Current Vascular Pharmacology·Niki KatsikiDimitri P Mikhailidis
Jan 1, 2010·The Open Cardiovascular Medicine Journal·Genovefa KolovouDimitri P Mikhailidis
Oct 13, 2011·Angiology·Niki KatsikiDimitrios T Karamitsos
May 9, 2012·Current Opinion in Cardiology·Anthony S WierzbickiDimitri P Mikhailidis
Oct 4, 2012·Journal of Cardiovascular Medicine·Niki KatsikiDimitri P Mikhailidis
Jan 3, 2013·Current Pharmaceutical Design·Niki KatsikiDimitri P Mikhailidis
Apr 2, 2013·Endocrine·Ioannis VasiliadisDennis V Cokkinos
Apr 18, 2013·Current Opinion in Cardiology·Genovefa Kolovou, Teik Chye Ooi
Dec 20, 2013·Current Vascular Pharmacology·Genovefa KolovouDimitri P Mikhailidis
Jan 24, 2014·Cardiorenal Medicine·Kunal ChaudharyAnnayya Aroor
Jun 25, 2014·Cardiovascular Diabetology·Enrique Z Fisman, Alexander Tenenbaum
Jul 22, 2014·BioMed Research International·Genovefa D KolovouSophie Mavrogeni
Oct 21, 2014·PloS One·Jong Hun KimUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 28, 2014·Expert Review of Cardiovascular Therapy·Niki KatsikiAsterios Karagiannis
Mar 1, 2015·Bosnian Journal of Basic Medical Sciences·Dilara KamanMehmet Akbulut
Apr 22, 2015·Diabetology & Metabolic Syndrome·Raquel de OliveiraRosario Dominguez Crespo Hirata
Jul 21, 2015·Annals of Pediatric Endocrinology & Metabolism·Min Sun Kim, Dae-Yeol Lee
Sep 1, 2015·International Journal of Cardiology·Simone BiscagliaRoberto Ferrari
Sep 22, 2015·International Journal of Environmental Research and Public Health·Anna LubkowskaWioleta Dudzińska
Nov 17, 2015·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Mumtaz TakirMehmet Kanbay

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Citations

Jul 3, 2021·Life·Antonina GiammancoAngelo Baldassare Cefalù

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Methods Mentioned

BETA
Genotyping
Polymerase Chain Reaction
ELISA

Software Mentioned

AdipoQ
SPSS

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