Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine

Oncotarget
Niraj LodhiKwangsun Stephen Suh

Abstract

Despite the great efforts for better treatment options for diffuse large B-cell lymphoma (DLBCL) (most common form of non-Hodgkin lymphoma, NHL) to treat and prevent relapse, it continues to be a challenge. Here, we present an overview of DLBCL and address the diagnostic assays and molecular techniques used in its diagnosis, role of biomarkers in detection, treatment of early and advanced stage DLBCL, and novel drug regimens. We discuss the significant biomarkers that have emerged as essential tools for stratifying patients according to risk factors and for providing insights into the use of more targeted and individualized therapeutics. We discuss techniques such as gene expression studies, including next-generation sequencing, which have enabled a more understanding of the complex pathogenesis of DLBCL and have helped determine molecular targets for novel therapeutic agents. We examine current treatment approaches, outline the findings of completed clinical trials, and provide updates for ongoing clinical trials. We highlight clinical trials relevant to the significant fraction of DLBCL patients who present with complex cases marked by high relapse rates. Supported by an increased understanding of targetable pathways in DLBCL...Continue Reading

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Citations

Aug 24, 2021·Computational and Mathematical Methods in Medicine·Ying LiuMing Jiang

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Methods Mentioned

BETA
flow cytometry
flow
PCR
biopsy
Assay
enzyme-linked immunosorbent assay
antisense oligonucleotides
ICE
xenograft
exome sequencing

Clinical Trials Mentioned

NCT00301821
NCT00118209
NCT00869999
NCT00931918
NCT02362997
NCT01024231
NCT02221739
NCT02752074
NCT01328626
NCT01652144

Software Mentioned

NanoString nCounter
qNPA

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