Biomarkers and peak oxygen uptake in patients with chronic lung disease

Respiration; International Review of Thoracic Diseases
Micha T MaederChristian Mueller

Abstract

Peak oxygen uptake (peak VO(2)) is a predictor of outcome in patients with lung disease. In these patients, peak VO(2) is typically determined by ventilation and gas exchange. However, it is not well known whether cardiac strain contributes to peak VO(2) in patients with chronic lung disease. To assess the relationship between several novel biomarkers reflecting different aspects of cardiac function and peak VO(2) in patients with chronic lung disease. Plasma concentrations of midregional pro-A-type natriuret- ic peptide (MR-proANP), midregional proadrenomedullin (MR-proADM), C-terminal proendothelin-1 (CT-proET-1), and C-terminal provasopressin (copeptin) were measured in 85 patients with a variety of chronic pulmonary diseases [age 57 ± 14 years, forced expiratory volume in the 1st second (FEV(1)) 76 ± 23% of the predicted value] undergoing maximal cardiopulmonary exercise testing (peak VO(2) 18.6 ± 6.6 ml/kg/min). Raised MR-proANP (r = -0.54), MR- proADM (r = -0.54), and CT-proET-1 (r = -0.49; p < 0.001 for all) but not copeptin (r = -0.05; p = 0.68) concentrations were associated with lower peak VO(2), and these associations were independent of age, gender, medication, FEV(1) and oxygenation. The relationship between MR-pro...Continue Reading

Citations

Aug 8, 2012·Respiration; International Review of Thoracic Diseases·Corey E VentetuoloDavid J Lederer
Sep 12, 2012·Journal of Cardiovascular Medicine·Beata Morawiec, Damian Kawecki
Jun 3, 2014·BMC Medicine·Kasper IversenLars Køber
Mar 20, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Fabian Sanchis-GomarGiuseppe Lippi
Jan 31, 2012·International Journal of Cardiology·Stephan von HaehlingBoris Bigalke

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