PMID: 22574090May 11, 2012Paper

Biomarkers and their involvement in the early diagnosis of right ventricular dysfunction in type 2 Diabetes Mellitus.

Journal of Medicine and Life
O VittosA Vittos

Abstract

During the last years, left ventricular dysfunction in diabetes was intensely studied and it is recognized as a complication of diabetes, while data regarding the right ventricular dysfunction is still incomplete. The aim of this study was to find a correlation between inflammatory biomarkers, adiponectin and right ventricular strain and strain rate properties in patients with diabetes mellitus type 2. We studied 29 patients with type 2 diabetes mellitus (DM), with coexisting cardiovascular complications, coronary artery disease and high blood pressure (group 1- DM+CV, aged 61.2 ± 4.2 years); and 22 patients with type 2 diabetes and controlled high blood pressure only, with no other coexisting cardiovascular complications (group 2- DM, aged 60.86 ± 4.4 years). We evaluated the right ventricular (rv) function through vector velocity imaging (vvi)and determined the inflammatory profile through assessment of the following biomarkers: high sensitivity C- reactive protein (hsCRP), tumor necrosis factor-alpha (TNF-alfa), lipoprotein associated phospholipase A2 (Lp-PLA2) and adiponectin level for each patient. VVI revealed significantly lower values of systolic strain and strain rates (SR) in the basal segment of the RV free wall in g...Continue Reading

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