Biomarkers as predictors of sudden cardiac death in coronary artery disease patients with preserved left ventricular function (ARTEMIS study)

PloS One
E Samuli LepojärviM Juhani Junttila

Abstract

Biomarkers have shown promising results in risk assessment of cardiovascular events. Their role in predicting the risk of sudden cardiac death (SCD) is not well established. We tested the performance of several biomarkers in risk assessment for SCD in patients with coronary artery disease (CAD) and preserved left ventricular function. The study population consisted of 1,946 CAD patients (68% male; mean age 66.9±8.6 yrs; type 2 diabetes (T2D) 43%) enrolled in the ARTEMIS study. The study subjects underwent examinations with echocardiography and measurement of several biomarkers. The primary endpoint of the study was SCD. During the mean follow up of 76±20 months 50 patients experienced SCD. Elevated high sensitive CRP (hs-CRP, p = 0.001), soluble ST2 (sST2, p<0.001), B-type natriuretic peptide (BNP, p<0.001), and highly sensitive TroponinT (hs-TnT, p<0.001) predicted the occurrence of SCD in univariate analysis. Using the optimal cutoff points, elevated sST2 (≥27.45ng/mL; hazard ratio [HR] 2.7; 95%CI 1.4-5.1, p = 0.003) and hs-TnT (≥15 ng/mL; HR 2.9; 95% CI 1.5-5.6, p = 0.002) were the strongest predictors of SCD followed by hs-CRP (HR 2.4; 95% CI 1.3-4.4, p = 0.004) and BNP (HR 1.9; 95% CI 1.0-3.7, p = 0.046) in adjusted analys...Continue Reading

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Citations

Jul 17, 2019·Journal of Cardiovascular Electrophysiology·Santeri NortamoJuha S Perkiömäki
Nov 27, 2019·International Journal of Molecular Sciences·Meihui TianZhipeng Cao
Feb 26, 2020·Journal of Clinical Medicine·Zornitsa ShomanovaLukas J Motloch
Oct 13, 2021·Current Opinion in Cardiology·Ying HongXiaoping Li

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Methods Mentioned

BETA
percutaneous
coronary artery bypass
ELISA

Clinical Trials Mentioned

NCT01426685

Software Mentioned

ARTEMIS
R
SPSS
R Statistics

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