Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis.

Arthritis Research & Therapy
Michael F SmithGerd Burmester

Abstract

One of the major challenges in rheumatology is to overcome the classification criteria that previously defined systemic lupus erythematosis, since the heterogeneity of the disease(s) appears to represent a complexity that probably substantially contributed to the failure of a number of recent trials. For those engaged in clinical trials, validated disease activity biomarkers that respond rapidly to treatment and are predictive of clinical response would greatly facilitate early decision-making around futility and dose selection. Likewise, use of validated patient stratification biomarkers possibly in conjunction with autoantibody profiles and disease manifestations will result in the recruitment of more homogeneous patient populations during later stage clinical studies, thereby decreasing size, costs, and risks in pivotal studies.

References

Jul 5, 1979·The New England Journal of Medicine·J J HooksA L Notkins
Jun 1, 1988·Arthritis and Rheumatism·R E Wolf, W G Brelsford
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Oct 8, 1999·The Journal of Clinical Investigation·K KatoT J Kipps
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·S D KhareH Hsu
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T K van den BergP R Crocker
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emily C BaechlerTimothy W Behrens
Mar 19, 2003·The Journal of Experimental Medicine·Lynda BennettVirginia Pascual
May 2, 2003·Arthritis Research & Therapy·William Stohl
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Feb 27, 2004·Autoimmunity·Mary K CrowJay Wohlgemuth
Dec 2, 2004·Nature Reviews. Drug Discovery·Joan T MerrillJill P Buyon
Dec 14, 2004·Arthritis and Rheumatism·Kyriakos A KirouMary K Crow
Aug 12, 2005·Current Opinion in Rheumatology·Chau-Ching LiuJoseph M Ahearn
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chungwen WeiIñaki Sanz
Nov 21, 2007·Annals of the Rheumatic Diseases·Michelle Petri
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Emma LindhMikael C I Karlsson
May 1, 2009·Arthritis and Rheumatism·Netta ShoenfeldYehuda Shoenfeld

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.