Biomarkers Associated With Leishmania infantum Exposure, Infection, and Disease in Dogs

Frontiers in Cellular and Infection Microbiology
Carla Maia, Lenea Campino

Abstract

Canine leishmaniosis (CanL) is a vector-borne disease caused by the protozoan Leishmania (Leishmania) infantum species [syn. L. (L.) infantum chagasi species in the Americas] which is transmitted by the bite of a female phlebotomine sand fly. This parasitosis is endemic and affect millions of dogs in Asia, the Americas and the Mediterranean basin. Domestic dogs are the main hosts and the main reservoir hosts for human zoonotic leishmaniosis. The outcome of infection is a consequence of intricate interactions between the protozoan and the immunological and genetic background of the host. Clinical manifestations can range from subclinical infection to very severe disease. Early detection of infected dogs, their close surveillance and treatment are essential to control the dissemination of the parasite among other dogs, being also a pivotal element for the control of human zoonotic leishmaniosis. Hence, the identification of biomarkers for the confirmation of Leishmania infection, disease and determination of an appropriate treatment would represent an important tool to assist clinicians in diagnosis, monitoring and in giving a realistic prognosis to subclinical infected and sick dogs. Here, we review the recent advances in the id...Continue Reading

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Citations

Jul 28, 2020·PLoS Neglected Tropical Diseases·Elisa CupolilloRenato Porrozzi
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Ana Alice Maia GonçalvesRodolfo Cordeiro Giunchetti
Jun 20, 2019·Frontiers in Veterinary Science·Javier Moreno
Aug 14, 2020·Parasitology Research·Selma GiorgioMarina Flóro E Silva
Jun 24, 2020·BMC Veterinary Research·Maria Alfonsa CavaleraAndrea Zatelli
Dec 10, 2020·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Asier BasurcoSergio Villanueva-Saz
Dec 15, 2020·Journal of the American Veterinary Medical Association·Catherine G LammChristian M Leutenegger
Oct 18, 2020·Veterinary and Comparative Oncology·Joaquim HenriquesMargarida Alves
Jun 19, 2021·Veterinary Parasitology·Sergio Villanueva-SazAntonio Fernández
Jul 6, 2021·Parasitology·Camila Aparecida de CarvalhoHeitor Franco de Andrade Júnior

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Methods Mentioned

BETA
PCR
ELISA
electrophoresis
enzyme-linked immunosorbent assay

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