Biomarkers associated with obstructive sleep apnea and morbidities: a scoping review

Sleep Medicine
Graziela De Luca CantoDavid Gozal

Abstract

To map potential biomarkers of obstructive sleep apnea (OSA)-associated morbidities in both adults and children, to identify gaps in current evidence, and to determine the value of conducting a full systematic review. A scoping review was undertaken of studies in patients with OSA that evaluated the potential value of biological markers in identifying OSA-associated morbidities. Retained articles were only those studies whose main objective was to identify morbidity biomarkers in subjects with OSA, the latter being confirmed with a full overnight polysomnography (PSG) in a laboratory or at-home settings. The methodology of the selected studies was classified using an adaptation of the evidence quality criteria recommended by the American Academy of Pediatrics. Additionally the biomarkers were categorized according to their potential clinical applicability. 572 citations were identified of which 48 met inclusion criteria. Thirty-four studies were conducted in adults and 14 involved children. Most of the studies evaluated blood biomarkers, and presented 31 potential diagnostic biomarkers. The majority of studies that performed explored blood-based biomarkers, with most not identifying definitive morbidity biomarkers. Of the poten...Continue Reading

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Citations

Aug 14, 2015·Chest·Hui-Leng TanDavid Gozal
Sep 22, 2015·Current Opinion in Pulmonary Medicine·David GozalAthanasios G Kaditis
May 28, 2016·Sleep & Breathing = Schlaf & Atmung·Zev FrimerElie Picard
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Mar 13, 2021·Panminerva Medica·Carlos A Rivas-EcheverríaCarlos A Rivas

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