Biomarkers for angiogenesis and antiangiogenic drugs in clinical oncology

The Breast : Official Journal of the European Society of Mastology
Francesco Bertolini

Abstract

The clinical use of anti-angiogenic drugs, alone or in combination with other drugs, is increasing in medical oncology. However, identifying the best suited drug and the optimal dosage and schedule for treatment of patients remain challenging. We reviewed data about surrogate biomarkers of angiogenesis and anti-angiogenic drug activity currently available in the literature. Circulating endothelial cells (CECs) and circulating endothelial progenitors (CEPs) have been found to have some predictive potential in some clinical trials involving advanced breast cancer patients. Molecular surrogate markers, on the other hand, are more scanty at the present time, because the identification of truly endothelial-cell-restricted genes and/or antigens has been so far more elusive. The search and validation of new biomarkers for angiogenesis and anti-angiogenic drug activity have many biological, technical and clinical facets which render this task particularly complex. An accurate planning of biomarker search and validation throughout future clinical studies is highly warranted.

References

Nov 5, 2002·Nature Reviews. Cancer·Shahin RafiiBeate Heissig
Oct 13, 2006·Nature Reviews. Cancer·Francesco BertoliniRobert S Kerbel
May 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anat Norden-ZfoniJohn V Heymach
Jun 15, 2007·Cancer Cell·Steven SeamanBrad St Croix
Oct 16, 2007·Drug Discovery Today·Francesco BertoliniRobert S Kerbel
May 9, 2008·The New England Journal of Medicine·Robert S Kerbel
Sep 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Silvia DellapasquaMarco Colleoni
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrizia MancusoFrancesco Bertolini

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Citations

Sep 17, 2010·Journal of the Royal Society, Interface·Suzanne M WattGrigorios Tsaknakis
Dec 5, 2009·The Journal of Pathology·Peter A HallRichard Poulsom

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