Biomarkers for Bisphosphonate-Related Osteonecrosis of the Jaw

Clinical Implant Dentistry and Related Research
Jin-Woo KimMyung-Rae Kim

Abstract

The aim of this study was to investigate a possible biomarker for bisphosphonate-related osteonecrosis of the jaw (BRONJ) in an animal model. Forty-eight Sprague-Dawley rats were randomly divided into the bisphosphonate group (n = 36), who were injected once a week with zoledronic acid, and the control group (n = 12), who were injected once a week with saline. After 6 weeks, surgical intervention was performed, and injections were continued up to 8 weeks. Rats in the bisphosphonate group were then further classified to the ONJ group, and the non-ONJ group, and biomarkers, including CTx, Glu-OC, TRACP 5b, RANKL, and OPG, were assessed at baseline (T0), at surgical intervention (T1), and at sacrifice (T2). Histomorphometric analysis for quantification of osteoclasts was performed. Repeated measures analysis of variance revealed that TRACP 5b levels and the RANKL/OPG ratio were significantly decreased over time in the ONJ group compared with the non-ONJ group (p < .05). At T2, the area under the curve was 0.807 for TRACP 5b (sensitivity: 88.9%, specificity 66.7% at cutoff) and 0.765 for the RANKL/OPG ratio (sensitivity: 77.8%, specificity 62.9% at cutoff). TRACP 5b showed a lower least significant change (29.6%) with lower intra-a...Continue Reading

References

Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peter I CroucherKarin Vanderkerken
Sep 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E Marx
Mar 5, 2004·JAMA : the Journal of the American Medical Association·Georg SchettJohann Willeit
Jun 10, 2004·JAMA : the Journal of the American Medical Association·Håkan Melhus
Jul 29, 2004·JAMA : the Journal of the American Medical Association·Lorenz C Hofbauer, Michael Schoppet
Feb 8, 2005·Trends in Molecular Medicine·T John Martin, Natalie A Sims
Aug 18, 2005·The Journal of Clinical Endocrinology and Metabolism·Angela Rogers, Richard Eastell
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Roland D Chapurlat, Pierre D Delmas
Nov 25, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K HenriksenM A Karsdal
Jan 18, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Morten A KarsdalKim Henriksen
Nov 21, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E MarxJuan J Ulloa
Jul 16, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·H Markus WeissHorst Schran
Jul 17, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Szulc, P D Delmas
Dec 17, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Steven LehrerRita Kogan
Mar 17, 2009·The Journal of Rheumatology·Aliya A KhanUNKNOWN Canadian Taskforce on Osteonecrosis of the Jaw
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroUNKNOWN American Association of Oral and Maxillofacial Surgeons
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Matthew R Allen, David B Burr
Nov 17, 2009·Calcified Tissue International·Anthony J Janckila, Lung T Yam
Jul 6, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tsu-Yi ChaoAnthony J Janckila
Aug 24, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Towy Sorel LazaroviciNoam Yarom
Oct 26, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sven OttoMatthias Schieker
Dec 15, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Junro YamashitaLaurie K McCauley
Aug 9, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Gayathri SubramanianSamuel Y P Quek
Nov 30, 2011·Nature Reviews. Rheumatology·Ian R Reid, Jillian Cornish
Feb 15, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Patrick G MorrisMonica N Fornier
Oct 18, 2012·Annual Review of Pharmacology and Toxicology·Kaixin Zhou, Ewan R Pearson
Dec 1, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David W DempsterA Michael Parfitt
Dec 19, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Parish P SedghizadehMichael Neely
Sep 23, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroFelice O'Ryan

❮ Previous
Next ❯

Citations

Oct 21, 2016·Clinical Oral Investigations·Jin-Woo KimIn-Ho Cha
Jan 21, 2017·Dento Maxillo Facial Radiology·Valesca S KothKaren Cherubini
Dec 22, 2017·Clinical Implant Dentistry and Related Research·Ki-Yeol KimIn-Ho Cha
Jan 13, 2018·Journal of Cellular Physiology·Jorge W Vargas-FrancoFrédéric Lézot
Sep 3, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jung-Hyun ParkJin-Woo Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Breast : Official Journal of the European Society of Mastology
Vittorio FuscoGiuseppina Campisi
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Vittorio FuscoGiuseppina Campisi
© 2022 Meta ULC. All rights reserved