Biomarkers for Detection and Monitoring of B16 Melanoma in Mouse Urine and Feces

Journal of Biomarkers
Aviv SeverYehuda Zeiri

Abstract

Melanoma is the most malignant type of skin cancer. Early detection of melanoma is thus critical for patient prognosis and survival. At present, examination by a skilled dermatologist followed by biopsy of suspicious lesions is the diagnostic gold standard. The aim of the present study was to examine an alternative and noninvasive method for the diagnosis of melanoma at an early stage. We identified and compared the volatile organic compounds (VOCs) in mouse urine and feces, before and after a subcutaneous injection of B16 melanoma cells. We identified a total of 16 VOCs in urine and 13 VOCs in feces that could serve as potential biomarkers. Statistical analysis significantly discriminated between the cancer and control groups. These results should be validated in a larger-scale animal study, after which a study could be designed in patients to develop a melanoma biomarker.

References

Sep 21, 2007·Nature Reviews. Cancer·Javier A Menendez, Ruth Lupu
Apr 17, 2008·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·A D'AmicoC Di Natale
Jul 31, 2010·CA: a Cancer Journal for Clinicians·Darrell S RigelRobert Friedman
Jul 21, 2011·Journal of Biochemistry·Mika Shirasu, Kazushige Touhara
Sep 21, 2012·Chemical Reviews·Meggie HakimHossam Haick
Jun 19, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jae KwakGeorge Preti
Aug 1, 1995·Journal of the American Society for Mass Spectrometry·S E Stein

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Citations

Nov 13, 2020·Critical Reviews in Analytical Chemistry·P Rodríguez-HernándezV Rodríguez-Estévez
Apr 13, 2021·Advanced Biology·Aylen Lisset Jaimes-MogollónRadu Ionescu
Jun 11, 2021·Frontiers in Veterinary Science·Pablo Rodríguez-HernándezJaime Gómez-Laguna

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Methods Mentioned

BETA
biopsy
xenografts

Software Mentioned

MS
SIMCA
SIMCA P +
ChemStation

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