Biomarkers for Early Cancer Diagnosis: Prospects for Success through the Lens of Tumor Genetics.

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Tommaso A DraganiFrancesca Colombo

Abstract

Thousands of candidate cancer biomarkers have been proposed, but so far, few are used in cancer screening. Failure to implement these biomarkers is attributed to technical and design flaws in the discovery and validation phases, but a major obstacle stems from cancer biology itself. Oncogenomics has revealed broad genetic heterogeneity among tumors of the same histology and same tissue (or organ) from different patients, while tumors of different tissue origins also share common genetic mutations. Moreover, there is wide intratumor genetic heterogeneity among cells within any single neoplasm. These findings seriously limit the prospects of finding a single biomarker with high specificity for early cancer detection. Current research focuses on developing biomarker panels, with data assessment by machine-learning algorithms. Whether such approaches will overcome the inherent limitations posed by tumor biology and lead to tests with true clinical value remains to be seen.

References

Sep 1, 1982·The American Journal of Surgical Pathology·B S SteinA R Kendall
Feb 9, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Irene VisintinGil Mor
Oct 25, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark H GreeneMitchell H Gail
Aug 14, 2010·Journal of the National Cancer Institute·Eleftherios P Diamandis
Aug 27, 2010·Science Translational Medicine·Harald MischakAntonia Vlahou
Sep 18, 2010·Nature Reviews. Genetics·Matthew MeyersonGad Getz
Mar 5, 2011·Cancer Prevention Research·Phuong L MaiMark H Greene
Mar 25, 2011·Nature·Lizzie Buchen
Apr 12, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Caroline J ChapmanJohn F R Robertson
Jul 13, 2012·Briefings in Bioinformatics·Wouter G TouwSacha A F T van Hijum
Oct 17, 2012·BJU International·Fritz H Schröder
Oct 19, 2012·Biomarkers in Medicine·Sukhwinder KaurSurinder K Batra
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Feb 21, 2014·BMC Medical Genomics·Peilin JiaZhongming Zhao
Mar 22, 2014·The New England Journal of Medicine·Thomas F ImperialeBarry M Berger
Mar 3, 2015·Journal of Cutaneous Pathology·Loren E ClarkeSancy Leachman
Mar 15, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mariam Jamal-HanjaniCharles Swanton
Apr 18, 2015·Clinical Chemistry·Michael J DuffyPatrick M M Bossuyt
Oct 13, 2015·World Journal of Gastroenterology : WJG·Nobuhiro TsuchiyaTetsuya Nakatsura
Oct 30, 2015·Clinical Chemistry·Patrick M BossuytUNKNOWN STARD Group
Apr 30, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura CiarloniGian Dorta
Jun 18, 2016·The Journal of Pathology·Hirofumi RokutanTatsuhiro Shibata
Jul 19, 2016·EBioMedicine·Lesley UttleyUNKNOWN Early Cancer Detection Consortium
Oct 13, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alicia HulbertJames G Herman
Nov 9, 2016·Translational Lung Cancer Research·Pablo ReclusaChristian Rolfo
Mar 9, 2017·Clinical Chemistry·John P A Ioannidis, Patrick M M Bossuyt
Apr 27, 2017·The New England Journal of Medicine·Mariam Jamal-HanjaniUNKNOWN TRACERx Consortium
May 30, 2017·Journal of Hepatocellular Carcinoma·Waleed Fateen, Stephen D Ryder
Jun 18, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Laura M López-SánchezAntonio Rodríguez-Ariza
Sep 16, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C Mayo-de-Las-CasasM A Molina-Vila
Sep 25, 2017·International Journal of Cancer. Journal International Du Cancer·Partha BasuRengaswamy Sankaranarayanan
Oct 27, 2017·Mass Spectrometry Reviews·Minnie JacobAnas M Abdel Rahman

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