Biomarkers for Heart Failure Prognosis: Proteins, Genetic Scores and Non-coding RNAs

Frontiers in Cardiovascular Medicine
Apurva ShrivastavaChristian Schulte

Abstract

Heart failure (HF) is a complex disease in which cardiomyocyte injury leads to a cascade of inflammatory and fibrosis pathway activation, thereby causing decrease in cardiac function. As a result, several biomolecules are released which can be identified easily in circulating body fluids. The complex biological processes involved in the development and worsening of HF require an early treatment strategy to stop deterioration of cardiac function. Circulating biomarkers provide not only an ideal platform to detect subclinical changes, their clinical application also offers the opportunity to monitor disease treatment. Many of these biomarkers can be quantified with high sensitivity; allowing their clinical application to be evaluated beyond diagnostic purposes as potential tools for HF prognosis. Though the field of biomarkers is dominated by protein molecules, non-coding RNAs (microRNAs, long non-coding RNAs, and circular RNAs) are novel and promising biomarker candidates that encompass several ideal characteristics required in the biomarker field. The application of genetic biomarkers as genetic risk scores in disease prognosis, albeit in its infancy, holds promise to improve disease risk estimation. Despite the multitude of bi...Continue Reading

References

Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H L SangerA K Kleinschmidt
Oct 21, 1992·Molecular and Cellular Biochemistry·A H KleineG J Van der Vusse
Feb 8, 1991·Cell·J M NigroB Vogelstein
Jan 1, 1986·European Journal of Clinical Pharmacology·K NakaoT Ban
Jan 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C CocquerelleB Bailleul
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·R Y YangF T Liu
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·M R BootcovS N Breit
Dec 31, 1997·Biochimica Et Biophysica Acta·R HromasL Lu
Jan 14, 2000·BMJ : British Medical Journal·G JacksonG Y Lip
Aug 9, 2002·European Journal of Heart Failure·Fátima CeiaUNKNOWN EPICA Investigators
Jan 3, 1964·Science·B CHANDLERS SPIEGELMAN
Jan 8, 2004·Clinical Chemistry·Nils G MorgenthalerAndreas Bergmann
Feb 21, 2004·Journal of the American College of Cardiology·Damien LogeartAlain Cohen Solal
Mar 2, 2005·Progress in Cardiovascular Diseases·Michael S Parmacek, R John Solaro
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicoletta FerrariAdriana Albini
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi NiizekiIsao Kubota
Nov 18, 2005·Cardiovascular Research·Toshio NishikimiHiroaki Matsuoka
Dec 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chulan KwonDeepak Srivastava
Feb 16, 2006·Biochimica Et Biophysica Acta·Jerka DumicMirna Flögel
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sakthivel SadayappanJeffrey Robbins
Dec 2, 2006·Circulation Research·Paola SecchieroGiorgio Zauli
Dec 7, 2006·Physiological Genomics·Angela ClerkPeter H Sugden
Jan 16, 2007·Cell Biology International·Heechul KimTaekyun Shin
Apr 19, 2007·Heart Failure Reviews·Candace Y W Lee, John C Burnett
May 5, 2007·Science·Anna HelgadottirKari Stefansson
May 5, 2007·Science·Ruth McPhersonJonathan C Cohen

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Citations

May 27, 2021·Seminars in Cell & Developmental Biology·Parvez KhanMohd Wasim Nasser

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Methods Mentioned

BETA
X-ray
gene

Software Mentioned

MANPRO
PRIMA
MOLITOR
Gal

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