Biomarkers for Pancreatic Neuroendocrine Neoplasms (PanNENs) Management-An Updated Review

Frontiers in Oncology
Martine BocchiniMassimiliano Mazza

Abstract

Pancreatic neuroendocrine tumors (PanNENs) are rare sporadic cancers or develop as part of hereditary syndromes. PanNENs can be both functioning and non-functioning based on whether they produce bioactive peptides. Some PanNENs are well differentiated while others-poorly. Symptoms, thus, depend on both oncological and hormonal causes. PanNEN diagnosis and treatment benefit from and in some instances are guided by biomarker monitoring. However, plasmatic monoanalytes are only suggestive of PanNEN pathological status and their positivity is typically followed by deepen diagnostic analyses through imaging techniques. There is a strong need for new biomarkers and follow-up modalities aimed to improve the outcome of PanNEN patients. Liquid biopsy follow-up, i.e., sequential analysis on tumor biomarkers in body fluids offers a great potential, that need to be substantiated by additional studies focusing on the specific markers and the timing of the analyses. This review provides the most updated panorama on PanNEN biomarkers.

References

Apr 1, 1991·The Journal of Pathology·Q HamidJ M Polak
Jul 1, 1991·Journal of Medical Genetics·E R MaherN Morton
Apr 1, 1987·American Journal of Clinical Oncology·J J LokichG Klee
Aug 1, 1995·The Journal of Clinical Endocrinology and Metabolism·R R Perry, A I Vinik
Aug 8, 1997·Science·M van SlegtenhorstD J Kwiatkowski
Oct 29, 1998·British Journal of Cancer·E BaudinM Schlumberger
May 25, 2002·Molecular and Cellular Biology·Latha ShivakumarMichael A White
Oct 23, 2002·Clinical Endocrinology·B MukhopadhyayS L Chew
Mar 21, 2003·The New England Journal of Medicine·Laurent TaupenotDaniel T O'Connor
Jul 3, 2003·Nature Reviews. Drug Discovery·Richard Frank, Richard Hargreaves
Jan 13, 2004·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Ken NishikuraYoichi Ajioka
May 22, 2004·Annals of the New York Academy of Sciences·Ulrich-Frank PapeUrsula Plöckinger
Jun 29, 2004·Advances in Anatomic Pathology·Lori A Erickson, Ricardo V Lloyd
Jan 6, 2005·Endocrine Reviews·Stephen J Marx, William F Simonds
Jan 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Thomas A MilneJay L Hess
Apr 16, 2005·The American Journal of Surgical Pathology·Hind NassarDavid S Klimstra
Oct 11, 2005·Journal of Neuroimmunology·Martina SchüllerRaymond Voltz
Nov 1, 2005·Cancer·Michelle N ZikusokaIrvin M Modlin
May 6, 2006·The Breast : Official Journal of the European Society of Mastology·Pankaj G Roy, Alastair M Thompson
Jun 28, 2006·World Journal of Surgical Oncology·Liesbeth M VeenendaalRichard van Hillegersberg
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claudia RoldoCarlo M Croce
Sep 27, 2006·Cancer Science·Sumika SaitoHironobu Sasano
Mar 28, 2007·Pathology Oncology Research : POR·Andrzej WincewiczStanislaw Sulkowski
Aug 9, 2007·Virchows Archiv : an International Journal of Pathology·Martin AnlaufGünter Klöppel
Jan 8, 2008·The Lancet Oncology·Irvin M ModlinAnders Sundin
Jun 3, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T R HalfdanarsonG M Petersen
Aug 16, 2008·Gastroenterology·David C Metz, Robert T Jensen

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Citations

Dec 29, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Antonio ViúdezAna De Jesús Acosta
Jul 3, 2021·Non-coding RNA·Alexandra KorotaevaAlexander Karpukhin
Dec 11, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Reut HalperinAmit Tirosh

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Methods Mentioned

BETA
imaging techniques
biopsy
biopsies
blood draw

Clinical Trials Mentioned

NCT03387592
NCT02586844
NCT03840460

Software Mentioned

NETest

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